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Clinical medicine

INFLUENCE OF VDR (RS731236) AND NOS3 (RS1143634) GENE VARIANTS ON CARDIOMETABOLIC PROFILE INDICATORS IN NEWBORNS

Published 2026-02-04

Authors:

V.I. Pokhylko
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0002-1848-0490
Y.I. Cherniavska
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0002-4522-7538
O.V. Yakovenko
Poltava State Medical University image/svg+xml
https://orcid.org/0009-0001-1062-9035
A.V. Davydenko
Poltava State Medical University image/svg+xml
https://orcid.org/0000-0002-4042-644X
Z.I. Rossokha
Shupyk National Healthcare University of Ukraine image/svg+xml
https://orcid.org/0000-0002-4767-7364
Abstract:
The study of genetic factors that influence the development of hypoxic-ischemic lesions in newborns is a relevant area of modern neonatology. The study analyzed the associations between NOS3 and VDR gene polymorphisms and clinical and cardiohemodynamic indicators in newborns, taking into account the mother's condition. Multivariate regression analysis showed that the CC VDR genotype was associated with a decrease in blood pressure (β=−8.17; p=0.016). The most significant predictor of blood pressure was venous blood pH (OR=0.61, p=0.004). The TT genotype of the NOS3 gene was associated with a significant increase in the risk of hypotension in newborns with hypoxic-ischemic CNS injury (OR=11.7; p=0.043). The identified trends in changes in cardiac function and vascular tone suggest a possible role for genetic mechanisms in shaping individual responses to hypoxia. The results obtained expand understanding of the pathogenesis of neonatal disorders and can inform risk stratification and treatment personalization.
Keywords:
VDR NOS3 newborns cardiometabolic profile Hypoxic-ischemic central nervous system injury gene variants blood pressure
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Publication:
«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 113-117
УДК 616-053.31:612.6.05:616.1:616-008.9-07
DOI:
https://doi.org/10.26724/2079-8334-2026-1-95-113-117