FEATURES OF HORMONAL CHANGES DURING PUBERTY IN GIRLS BORN TO WOMEN WITH GESTATIONAL DIABETES

Authors:

Abstract:

With the purpose to assess the features of hormonal changes in girls born to mothers with gestational diabetes, the 25 pubertal girls born to mothers with gestational diabetes and 30 practically healthy girls. The sexual development, indicators of carbohydrate metabolism and the levels of follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, prolactin, cortisol, triiodothyronine, thyroxine, dehydroepiandrosterone sulfate, 17-hydroxyprogesteron, estradiol, and testosterone were determined. In the girls from mother with gestational diabetes the hirsutism index was significantly higher (P<0.05), than in healthy girls (15.3±0.06 and 8.3±1.8, respectively). The indicators of secondary sexual characteristics in girls from mothers with gestational diabetes were lower than in healthy girls (P<0.05). In pubertal girls born to women with gestational diabetes, follicle-stimulating hormone, thyroid-stimulating hormone and estradiol were significantly lower than in practically healthy girls (P<0.05). A statistically significant increase in luteinizing hormone, prolactin, triiodothyronine and thyroxine, dehydroepiandrosterone sulfate, 17-hydroxyprogesteron, and testosterone was observed (P<0.05).

Keywords:

gestational diabetes mellitus puberty hypoestrogenism hyperprolactinemia adrenal-ovarian hyperandrogenism

References:

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Publication:

«World of Medicine and Biology» Vol. 21 No. 92 (2025) , с. 121-124
УДК 616.2:616.379-008.64

DOI:

https://doi.org/10.26724/2079-8334-2025-2-92-121-124