English Ukrainian
Clinical medicine

CHARACTERISTICS OF REPRODUCTIVE FUNCTION DISORDERS IN PATIENTS WITH ENDOMETRIAL HYPERPLASIA WITHOUT ATYPIA

Published 2024-10-16

Authors:

Z.S. Huseynova
Abstract:
The study involved 118 women who were divided into three groups: Group C – control, practically healthy women (50 women), Group I – women with endometrial hyperplasia and reproductive dysfunction (43 patients), Group Ⅱ – women with reproductive disorders and endometrial hyperplasia in combination with one of the other benign uterine pathologies (25 patients). Patients with an increased body mass index and advancing age were found to have a higher incidence of endometrial hyperplasia and reproductive dysfunction. In patients with endometrial hyperplasia, menstrual dysfunction was manifested by menometrorrhagia, which was accompanied by posthemorrhagic anemia. Reproductive dysfunction in patients with endometrial hyperplasia is characterized by infertility. In Group I, primary infertility predominates; in Group II, secondary infertility is more common, and infertility lasting more than 5 years is more frequent in Group II. Levels of estradiol were higher, and progesterone levels were lower compared to the control group. In the group with endometrial hyperplasia, changes in the hemodynamic parameters of the uterine arteries were observed: the systole-diastolic ratio, resistance index, and pulsation index in both arteries were lower than in the control group. When pregnancy occurred after treatment in patients with endometrial hyperplasia, no significant pathologies were observed during pregnancy, in its outcomes, or in the condition of the newborns. Timely assessment and contribute to pathogenetically based treatment and the realization of reproductive desires.
Keywords:
endometrial hyperplasia menstrual dysfunction reproductive dysfunction infertility
References:
  1. Aleksioska IP, Antovska V, Dabeski D, Ilieva N, Kjaev I, Markova AD, et al. The impact of obesity and fat distribution on endometrial cancer risk in postmenopausal patients. J Morphol Sci. 2023;6(2):157–164. doi:10.55302/JMS2362157.
  2. An H, Li T, Huang K, Shi H, Wang C, Chu T et al. Pregnancy outcomes in infertile patients with endometrial hyperplasia with or without atypia undergoing in vitro fertilization: the early-follicular long protocol is superior to midluteal long protocol. Front. Endocrinol. 15:1314432. doi: 10.3389/fendo.2024.1314432.
  3. Boichuk AV, Shadrina VS, Vereshchahina TV. Hyperplasia of endometrium – a modern system-pathogenetic view on the problem (literature review): (literature review). Actual problems of pediatrics, obstetrics and gynecology. 2019;(1):67–72. https://doi. org/10.11603/24116-4944.2019.1.9906.
  4. Cree IA, White VA, Indave BI, Lokuhetty D. Revising the WHO classification: female genital tract tumours. Histopathology. 2020 Jan;76(1):151–156. doi: 10.1111/his.13977.
  5. Emons G, New WHO Classification of endometrial hyperplasias. Emons G, Bechmann NW, Schimidt DP. Mallman; Uterus commission of the Gynecological Oncology Working Group (AGO) Geburtshilfe Fraunheilkd. 2015 Feb;75 (2):135–136.
  6. Erdem B, Aşıcıoğlu O, Seyhan NA, Peker N, Ülker V, Akbayır Ö. Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?. Int. J. Surg. 2018; 53:350–353.
  7. Laza-Parrochia F, Romero C, Valladares L, Vega M. Endometrium and steroids, apathologic overview. Steroids. 2017; 126:85–91. https://doi.org/10.1016/j.steroids.2017.08.007.
  8. Farhane FZ, Alami Z, Bouhafa T, Elmazghi A, Hassouni K. Primary squamous cell carcinoma of endometrium: case report and literature review. Pan Afr. Med. J. 2018;4 (30):8. https://doi.org/doi:10.11604/pamj.2018.30.8.8983.
  9. Islam MS, Afrin S, Jones SI, Segars J. Selective progesterone receptor modulators—mechanisms and therapeutic utility. Endocrin Rev. 2020;41(5):bnaa012. doi: 10.1210/endrev/bnaa012.
  10. Laza-Parrochia F, Romero C, Valladares L, Vega M. Endometrium and steroids, a pathologic overview. Steroids. 2017 Oct;126: 85–91. doi: 10.1016/j.steroids.2017.08.007.
  11. Oglat AA, Matjafri MZ, Suardi N, Oqlat MA, Abdelrahman MA, Oqlat AA. A review of medical Doppler ultrasonography of blood flow in general and especially in common carotid artery. JMed Ultrasound.2018; 26:3–13.
  12. Ou H, Yu Q. Efficacy of aspirin, prednisone, and multivitamin triple therapy in treating unexplained recurrent spontaneous abortion: A cohort study. Int J Gynaecol Obstet 2020; 148:21-6. doi: 10.1002/ijgo.12972.
  13. Russo M, Newell JM, Budurlean L, Houser KR, Sheldon K, Kesterson J et al. Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma. Cancer. 2020 Jun 15;126(12):2775–2783. doi: 10.1002/cncr.32822.
  14. Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017 Mar 1;23(2):232–254. doi: 10.1093/humupd/dmw042.
  15. Vijayaraghavan A, Jadhav C, Pradeep B, Bindu H, Kumaran S. A Histopathological Study of Endometrial Biopsy Samples in Abnormal Uterine Bleeding. Cureus. 2022;14(11): e 31264. doi: 10.7759/cureus.31264.
Publication:
«World of Medicine and Biology» Vol. 20 No. 90 (2024) , с. 43-47
УДК 618.14-006.5:616
DOI:
https://doi.org/10.26724/2079-8334-2024-4-90-43-47