| About the author: |
Hladkykh F.V., Stepaniuk N.H., Vernygorodskii S.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Nonsteroidal anti-inflammatory drugs are widely used in many fields of medicine for the treatment of inflammatory processes of various etiologies and is one of the most clinically meaningful groups of drugs. Serious side effects of these drugs are their gastrotoxicity, nephrotoxicity, hepatotoxicity, and others. In previous studies, we have proved the effectiveness of combined use of Ukrainian antispasmodics with the polytropical pharmacological properties of vinoborone and a non-steroidal anti-inflammatory drug ibuprofen for potentiating the therapeutic properties of the latter and diminishing its toxicity to the mucous membrane of the stomach. The aim of the study was to characterize the effect of ibuprofen and its combination with vinoboron on the liver, kidney and adrenal glands, according to morphological studies on the model of adjuvant arthritis in rats. The study was conducted on 28 sexually mature nonlinear male rats. Adjuvant arthritis was modeled by sublingual administration of full Freund's adjuvant. Treatment of adjuvant arthritis was performed from day 14 to day 28, by intragastric administration of the investigational drugs. The conducted study showed that vinoboron against ibuprofen in the treatment of experimental adjuvant arthritis reduces hepatotoxic and nephrotoxic effects of ibuprofen. |
| Tags |
vinoboron, ibuprofen, adjuvant arthritis, non-steroidal anti-inflammatory drugs, hepatotoxicity, nephrotoxicity |
| Bibliography |
- Avtandylov H. H. Osnovyi patolohoanatomycheskoi praktyky. Rukovodstvo (yzdanye trete dopolnennoe) / H. H. Avtandylov // – M.: Rossyiskaia medytsynskaia akademyia posledyplomnoho obrazovanyia. – 2007. – 480 s.
- Golofeevskiy V. Yu. Sochetannaya okraska gistologicheskih srezov osnovnyim korichnevyim i prochnyim zelenyim / V. Yu. Golofeevskiy, S. G. Scherbak // Arhiv anatomii, gistologii i embriologii. – 1987. – No. 4. – S. 101.
- Gorshkov A. N. Morfologicheskie aspektyi nefrotoksicheskogo deystviya nesteroidnyih protivovospalitelnyih sredstv / A. N. Gorshkov, I. V. Marusov, O. D. Yagmurov [i dr.] // - Nefrologiya. – 2013. – T. 17, No. 1. – S. 73-77.
- Hladkykh F. V. Suchasni shliakhy poslablennia ultserohennosti nesteroidnykh protyzapalnykh zasobiv : dosiahnennia, nevyrisheni pytannia ta shliakhy optymizatsii / F. V. Hladkykh, N. H. Stepaniuk // Zaporozhskyi medytsynskyi zhurnal. – 2014. – No. 2. – S. 82-86.
- Hladkykh F. V. Vinboron: pershyi ukrainskyi hastroprotektor – ahonist vaniloidnykh retseptoriv (TRPV1) / F. V. Hladkykh, N. H. Stepaniuk // Farmakolohiia ta likarska toksykolohiia. – 2016. – No.4-5 (50). – S. 20-29.
- Gladkih F. V. Izuchenie sostoyaniya kletochnogo gomeostaza slizistoy obolochki zheludka kryis na modeli revmatoidnogo artrita, lechennogo ibuprofenom i ego kombinatsiey s vinboronom / F. V. Gladkih, N. G. Stepanyuk, S. V. Vernigorodskiy // Farmatsiya i farmakologiya. – 2016. – T. 4, No.3. – S. 68-83. – DOI: http://dx.doi.org/10.19163/2307-9266-2016-4-3-68-83.
- Hladkykh F. V. Otsinka efektyvnosti likuvannia eksperymentalnoho revmatoidnoho artrytu ibuprofenom ta yoho kombinatsiieiu z vinboronom za danymy konusno-promenevoi kompiuternoi tomohrafii ta tsyfrovoi renthenohrafii zadnikh kintsivok shchuriv / F. V. Hladkykh, N. H. Stepaniuk, V. O. Student, Ya. Ya. Pohrebennyk, B. Ye. Yurkevych // Farmakolohiia ta likarska toksykolohiia. – 2017. – No. 1 (52). – S. 12-24.
- Karateev A. E. Kolichestvennaya i kachestvennaya otsenka riska oslozhneniy pri ispolzovanii nesteroidnyih protivovospalitelnyih preparatov kak osnova formirovaniya rekomendatsiy po ih kontrolyu i profilaktike / A. E. Karateev // Sovremennaya revmatologiya. – 2014. – No. 1. – S. 64-72.
- Memetova E. Ya. Morfogenez tkani nadpochechnikov u eksperimentaotnyih zhivotnyih s modelirovannyim adyuvantnyim artritom / E. Ya. Memetova, N. N. Kaladze, A. K. Zagorulko // Verhnevolzhskiy meditsinskiy zhurnal. – 2014. – T. 12, Vyip. 1. – S. 34-39.
- Nasonov E. L. Revmatologiya. Natsionalnoe rukovodstvo / E. L. Nasonov, V. A. Nasonova // – M.: «GEOTAR-Media», - 2008. – 737 s.
- Pentiuk N. O. Nefrotoksychnist nesteroidnykh protyzapalnykh preparativ ta yii korektsiia trymetazydynom (kliniko-eksperymentalne doslidzhennia): dys... kand. med. nauk: 14.01.28 / Pentiuk Nataliia Oleksandrivna; Vinnytskyi derzh. medychnyi un-t im. M.I. Pyrohova. - Vinnytsia, - 2001. – 203 s.
- Ryibolovlev Yu. R. Dozirovanie veschestv dlya mlekopitayuschih po konstantam biologicheskoy aktivnosti / Yu. R. Ryibolovlev, R. S. Ryibolovlev // Dokladyi AN SSSR. – 1979. – T. 247., No.6. – S. 1513–1516.
- Stefanov O. V. Doklinichni doslidzhennia likarskykh zasobiv: metod. rekomend. // O. V. Stefanova // - K.: VD«Avitsena». – 2001. – 527 s.
- Chekman I. S. Nesteroidni protyzapalni preparaty: efektyvnist, dostupnist i pryiniatnist dlia patsiienta. Farmakodohliad za bezpekoiu zastosuvannia: monohrafiia / I. S. Chekman, O. P. Viktorov, N. O. Horchakova [ta in.] // - K.: Polihraf plius, - 2011. – 117 s.
|
| Publication of the article |
«World of Medicine and Biology» №4(62), 2017 year, 127-131 pages, index UDK [615.262:616.276]:616.72-002.772:612.08 |
| DOI |
10.26724/2079-8334-2017-4-62-127-131 |
