THE CONTENT OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN THE BLOOD SERUM OF YOUNG PATIENTS WITH ARTERIAL HYPERTENSION

Authors:

Abstract:

The purpose of the work was to study the content of neutrophil gelatinase associated lipocalin in blood serum and its relationship with parameters of intrarenal hemodynamics in young patients with arterial hypertension. It was established that in such patients the maximum value of neutrophil gelatinase associated lipocalin content in blood serum was characteristic of individuals with a reduced glomerular filtration speed compared to patients with preserved glomerular filtration speed and healthy individuals. The duplex scan data of the renal arteries showed that in patients with arterial hypertension of young age a decrease in the end-diastolic velocity of arterial blood flow and increasing the resistance index was recorded, more pronounced when the rate of glomerular filtration decreases, that confirms their diagnostic significance in the assessment of morpho-functional changes in the kidneys.

Keywords:

neutrophil gelatinase associated lipocalin arterial hypertension in young people duplex scanning of the renal arteries glomerular filtration speed

References:

1. Katerenchuk IP. Klinichna otsinka, diahnostychne i prohnostychne znachennia deiakykh suchasnykh laboratornykh doslidzhen u patsiientiv z ishemichnoyiu khvoroboiu sertsia. Kardyolohyia: ot nauky k praktyke. 2019;3(37):70–81. doi: https://doi.org/10.30702/card:sp.2019.08.037/0307081 [in Ukrainian]
2. Danquah M, Owiredu WKBA, Jnr BAE, Serwaa D, Odame Anto E, Peprah MO, Obirikorang C, Fondjo LA. Diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for detection of renal failure in hypertensives: a case-control study in a regional hospital in Ghana. BMC Nephrol. 2023 Apr 26;24(1):114. doi: 10.1186/s12882-023-03120-6.
3. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet 2020, 395, 709–733.
4. Heine GH, Gerhart MK, Ulrich C, Köhler H, Girndt M. Renal Doppler resistance indices are associated with systemic atherosclerosis in kidney transplant recipients. Kidney Int. 2005;68(2):878–885.
5. Lameire NH, Levin A, Kellum JA, Cheung M, Jadoul M, Winkelmayer WC, Stevens PE; Conference Participants. Harmonizing acute and chronic kidney disease definition and classification: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney Int. 2021 Sep;100(3):516–526. doi: 10.1016/j.kint.2021.06.028.
6. Meher M, Pradhan S, Pradhan SR. Risk Factors Associated With Hypertension in Young Adults: A Systematic Review. Cureus. 2023 Apr 12;15(4): e37467. doi: 10.7759/cureus.37467.
7. Mulè G, Castiglia A, Cusumano C, Scaduto E, Geraci G, Altieri D, Di Natale E, Cacciatore O, Cerasola G, Cottone S. Subclinical Kidney Damage in Hypertensive Patients: A Renal Window Opened on the Cardiovascular System. Focus on Microalbuminuria. Adv Exp Med Biol. 2017; 956:279-306. doi: 10.1007/5584_2016_85.
8. Ohta Y, Fujii K, Arima H, Matsumura K, Tsuchihashi T. Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. J Hypertens. 2005;23(10):1905–1911.
9. Sidenur B, Shankar G. A Cross-Sectional Study of Hypertension among 20-40 Years Old Residing in an Urban Area of Bagalkot City, North Karnataka. Indian J Community Med. 2023 Jan-Feb;48(1):98–102. doi: 10.4103/ijcm.ijcm_255_22.
10. Shin D, Choi J, Lee HY. Suboptimal control status of young hypertensive population. Clin Hypertens. 2023 May 1;29(1):13. doi: 10.1186/s40885-023-00237-6.
11. Song E, Fan P, Huang B, Deng H, Cheung BMY, Félétou M, et al. Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. J Am Heart Assoc. 2014;3(2): e000837
12. Wang Y, Li F, Chu C, Zhang X, Zhang XY, et al. Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study. EClinicalMedicine. 2022 Apr 28; 48:101420. doi: 10.1016/j.eclinm.2022.101420.

Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 36-40
УДК 616.12-008.331.1-053.81-078

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-36-40