СLINICAL-EPIDEMIOLOGICAL, IMMUNOLOGICAL, MICROBIOLOGICAL ASPECTS AND PREVALENCE OF BLASTOCYSTOSIS AMONG THE POPULATION OF THE REPUBLIC OF AZERBAIJAN

Authors:

Abstract:

Blastocystosis is one of the least studied infectious diseases among intestinal protozoans in the Republic of Azerbaijan; only several studies have been conducted in this field, dating back 30–35 years. The attitude towards blastocystosis worldwide, including in the Republic of Azerbaijan, has not been unambiguous. We have discovered epidemiological features and regional characteristics. As a result, three subtypes of Blastocystis hominis have been identified – ST3, ST2, and ST4. For example, ST3 was found the most, followed by ST2, and relatively less ST4. Therefore, it is essential to study the prevalence of B.hominis among populations in different regions and countries and to study the role in human pathologies, its pathogenesis, and clinical course caused by different species and genotypes, which lead to the effectiveness of treatment.

Keywords:

blastocystosis genotypes morbidity opportunistic infection cytokines intestinal microbiota conditionally pathogenic microflora diarrhea

References:

1. Bálint A, Dóczi I, Bereczki L, Gyulai R, Szucs M, Farkas K, et al. Do not forget the stool examination! – Cutaneous and gastrointestinal manifestations of Blastocystis sp. infection. Parasitol. Res. 2014; 113:1585–1590. doi: 10.1007/s00436-014-3805-0.
2. Beghini F, Pasolli E, Truong TD, Putignani L, Cacciò SM, Segata N. Large-scale comparative metagenomics of Blastocystis, a common member of the human gut microbiome. ISME J. 2017; 11:2848–2863. doi: 10.1038/ismej.2017.139.
3. Dagci H, Kurt Ö, Demirel M, Mandiracioglu A, Aydemir S, Saz U, et al. Epidemiological and diagnostic features of Blastocystis infection in symptomatic patients in Izmir province, Turkey. Iran. J. Parasitol. 2014; 9:519–51929.
4. Deng L, Wojciech L, Gascoigne NRJ, Peng G, Tan KSW. New insights into the interactions between Blastocystis, the gut microbiota, and host immunity. PLoS Pathog. 2021;17: e1009253. doi: 10.1371/journal.ppat.1009253.
5. Gancho OV, Moshel TM, Boychenko OM, Bublii TD, Kostyrenko OP, Popovіch IYu, et al. Herbal medicines antimicrobial effect. Georgian medical news. 2022; 7(328): 88–91.
6. Nourrisson C, Scanzi J, Pereira B, NkoudMongo C, Wawrzyniak I, Cian A. Blastocystis is associated with decrease of fecal microbiota protective bacteria: comparative analysis between patients with irritable bowel syndrome and control subjects. PLoS One. 2014 Nov 3;9(11): e111868. doi: 10.1371/journal.pone.0111868.7. Rudzińska M, Sikorska K. Epidemiology of Blastocystis Infection: A Review of Data from Poland in Relation to Other Reports. Pathogens. 2023 Aug 16;12(8):1050. doi: 10.3390/pathogens12081050.
7. Scanlan PD, Stensvold CR, Rajilić-Stojanović M, Heilig HG, De Vos WM, O’Toole PW, et al. The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota. FEMS Microbiol Ecol 2014; 90: 326-30.
8. Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D, Wardle-Jones H, et al. Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach. Transgenic Res. 2015 Oct;24(5):921–7. doi: 10.1007/s11248-015-9897-1.
9. Seyer A, Karasartova D, Ruh E, Güreser AS, Turgal E, Imir T, et al. Epidemiology and Prevalence of Blastocystis spp. in North Cyprus. Am J Trop Med Hyg. 2017 May;96(5):1164–1170. doi: 10.4269/ajtmh.16-0706.
10. Stensvold CR, Clark CG. Current status of Blastocystis: A personal view. Parasitol. Int. 2016; 65:763–771. doi: 10.1016/j.parint.2016.05.015.

Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 118-121
УДК 616.155.02

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-118-121