DYNAMICS OF EXPRESSION OF CARBOHYDRATE DETERMINANTS OF FUCOSE-SPECIFIC LECTIN OF THE BARK OF GOLDEN RAIN IN THE MUCOSA OF THE ATTACHED PART OF THE GUMS OF RATS UNDER CHRONIC ETHANOL INTOXICATION

Authors:

Abstract:

The purpose of the study was to determine the dynamics of expression of carbohydrate determinants of fucose-specific lectin of the bark of golden rain in the mucous membrane of the attached part of the gums of rats under chronic ethanol intoxication. The rats were administered 12 mg/kg of 40 % ethanol 4 times a day gastrointestinally. On days 5 and 12, the animals were removed from the experiment. Determination of carbohydrate components of the structural elements of the mucous membrane of the attached part of the gums was performed by lectin histochemistry. On the fifth day of observation, the study of the specificity of receptor binding to the fucose-specific lectin of the bark of the golden rain on the structural components of the epithelial plate of the attached part of the gums of rats revealed that the expression of receptors on the horny scales and basement membrane decreased from moderate to weak. The reaction of receptors to the lectin of the bark of the golden rain on the basal membranes of the vessels of the hemomicrocirculatory channel increased from moderate to strong. On the 12th day of observation, the components of the epithelial plate of the attached part of the gums of rats showed a stable weak degree of expression of receptors to the lectin of the bark of the golden rain in comparison with the previous period of the experiment.

Keywords:

lectins mucous membrane chronic ethanol intoxication attached part of the gingiva

References:

1. Bagrіy M, Dіbrova VA, Popadinets OG, Grishchuk MІ. Metodyky morfolohіchnykh doslіdzhen: Monografіya. Vіnnytsya: Nova knyha, 2016. 328 s. [in Ukrainian]
2. Bilash VP. Porivnyalna kharakterystyka vuhlevodnykh zalyshkiv na strukturnykh komponentakh kintsevykh sekretornykh viddiliv pidnyzhnyoshchelepnykh slynnykh zaloz lyudyny ta deyakykh laboratornykh tvaryn. Svit medytsyny ta biolohiyi. 2017; 1 (59): 99–103. [in Ukrainian]
3. Bilash SM, Boruta NV, Starchenko II. Lektynokhimichna kharakterystyka klitynnykh elementiv erytroblastnoho ostrivtsia chervonoho kistkovoho mozku u shchuriv pry vvedeni kriokonservovanoyi platsenty. Svit medytsyny ta biologiyi. 2017; 3(61): 83–5.doi:10.26724/2079-8334-2017-3-61-83-85 [in Ukrainian]
4. Varzhapetian SD, Huliuk AH. Vyvchennia rozpodilu hliukokonyuhativ vperspektyvi rozrobok mistsevoyi terapiyi stomatohennykh verkhnoshchelepnykh synusytiv. Svit medytsyny ta biologiyi. 2018; 2 (64): 126–31. doi: 10.26724/2079-8334-2018-2-64-126-131 [in Ukrainian]
5. Yeroshenko GA, Tymoshenko YuV. Dynamika ekspresiyi vuhlevodnykh determinant strukturnykh komponentiv slyzovoyi obolonky zalozystoyi zony tverdoho pidnebinnia za umov eksperymentalnoyi hiposalivatsiyi. Svit medytsyny ta biologiyi. 2018; 1 (63): 123–26. doi: 10.26.724/2079-8334-2018-1-63-123-126 [in Ukrainian]
6. Іvanochko VM. Morfologіchniy stan strukturnykh komponentіv fіltratsіyno-reabsorbtsіynoho baryeru nyrok u normі і pry khronіchnіy alkoholіzatsіyi napoyamy rіznoyi yakostі і mіtsnostі [dysertatsiya]. Ternopіl, 2003.19 s. [in Ukrainian]
7. Kazakova KS, Yeroshenko GA, Shevchenko KV. Toksychnyi vplyv etanolu na slyzovi obolonky. Svit medytsyny ta biologiyi. 2017; 3 (61):169–73. doi: 10.26724/2079-8334-2017-3-61-169-173 [in Ukrainian]
8. Kazakov OA. Suchasnyi stan problemy pidlitkovoho alkoholizmu v Ukraini. Svit medytsyny ta biologiyi. 2017;2(60):54–6. [in Ukrainian]
9. Chemerys NM. Medyko-sotsialni aspekty problemy vzhyvannia psykhoaktyvnykh rechovyn moloddiu (ohliad naukovoi literatury). Ukraina. Zdorovia natsii. 2017; 3: 285–291. [in Ukrainian]
10. Shehedin AYu, Yashchenko AM, Lutsyk OD. Eksponuvannia hlikokonyuhativ u postnatalnomu morfohenezi yayechka shchura za danymy pasreaktsiyi ta lektynovoyi histokhimiyi. Svit medytsyny ta biologiyi. 2017; 2(60):156–60. [in Ukrainian]

Publication:

«World of Medicine and Biology» Vol. 19 No. 85 (2023) , с. 216-219
УДК 616.311.2-018.2:615.917.262:615.322-02:582.736.3]-092.9

DOI:

https://doi.org/10.26724/2079-8334-2023-3-85-216-219