INFLUENCE OF EXCESSIVE NIGHTTIME ACTIVITY ON THE RISK OF ISCHEMIC CEREBRAL STROKE EVENT AND ITS COURSE FEATURES

Authors:

Abstract:

Clinical neurological and neuroimaging examination of 300 patients with ischemic stroke was performed. The control group included 40 patients without signs of acute cerebral stroke (men - 21, women - 19) aged 46 to 76 years (mean age being 62.6 ± 10.2 years). The data obtained confirmed that the important role of excessive nighttime activity (ENA) is characteristic of all groups of patients, but 100% correlation is observed in patients with nocturnal strokes. In patients with ENA there are two peaks of blood pressure increase: - 9:00 and 21:00. Patterns of blood pressure disorders at night were as follows: 68.4% (n = 13) - night peaker, 26.3% (n = 5) - non dipper, 5.2% (n = 1) - dipper subtype. Against the background of an optimized stroke prevention program, the incidence of recurrent ischemic strokes was by 2.09 times lower than in the control group within 2 years. The present study results show the importance of ENA for the diagnosis and pathogenesis of acute ischemic stroke.

Keywords:

stroke excessive nighttime activity onset time stroke risk prevention

References:

1. Zozulya I, Zozulya A, Volosovets A. Complications of ischemic stroke: Diagnostics, treatment, prevention and rehabilitation. Psychiatry, Psychotherapy and Clinical Psychology 2017, T. 8, №3:375-381 [in Ukrainian]
2. Mishchenko TS. Epidemiologiya tserebrovaskulyarnykh zabolevaniy i organizatsiya pomoshchi bolnym s mozgovym insultom v Ukraine. Ukr. vísn. psikhonevrolohiyi. 2017; 25(1):22-4. [in Russian]
3. Douma LG, Gumz ML. Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med. 2018;119:108–114.
4. Fodor D. M., Gonganau-Nitu D., Perju-Dumbrava L. “Circadian pattern of ischemic stroke onset,” in Human Vet Med Bioflux, vol. 6, pp. 132–139, 2014.
5. Choi Y. I., Seo I.-K., Kim D.-E. et al., “Same pattern of circadian variation according to the season in the timing of ischemic stroke onset: preliminary report,” Sleep Medicine Research, vol. 6, no. 2, pp. 72–76, 2015.
6. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ. Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation. 2014 Jan 21;129(3):e28-e292.
7. Shanmugam V, Wafi A, Al-Taweel N, Busselberg D. Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease. J Local Global Health Sci. 2013; 2013:3.
8. Wirtz PH, von Känel R. et al. Psychological Stress, Inflammation, and Coronary Heart Disease. Curr Cardiol Rep. 2017 Sep 20;19(11):111
9. Yadegarfar G, Shahabi J, Garakyaraghi M, The association of anthropometric indices and cardiac function in healthy adults. ARYA Atheroscler. 2019 Jan;15(1):9-13.

Publication:

«World of Medicine and Biology» Vol. 16 No. 71 (2020) , с. 22-26
УДК 616-079.3. 616.831-005.6

DOI:

https://doi.org/10.26724/2079-8334-2020-1-71-22-26