CYTOSTATIC IMPACT ON SPERMATOGENIC CELLS ULTRASTRUCTURE AND ITS CORRECTION BY CHONDROITIN SULPHATE

Authors:

Abstract:

The article presents data on the specific changes in the animal spermatogenic cells ultrastructure under the impact of doxorubicin hydrochloride. It is shown that the toxic effect of cytostatics is accompanied by the development of dystrophic and destructive changes in the rat testes cells. Under the influence of chondroitin sulfate, the gradual restoration of reparative processes in the rat spermatogenic cells exposed to doxorubicin hydrochloride was carried out. Chondroitin sulfate facilitated the turnover of the structure of the filaments plasmatic membrane areas after the toxic effect of the cytostatic, which ensures normal sperm motility.

Keywords:

testes ultrastructure spermatogenesis chondroitin sulfate cytostatics doxorubicin hydrochloride

References:

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Publication:

«World of Medicine and Biology» Vol. 15 No. 68 (2019) , с. 171-174
УДК 591.463.2: 615.277.3: 616-08

DOI:

https://doi.org/10.26724/2079-8334-2019-2-68-171-174