ANALYSIS OF THE EFFECTIVENESS AND SAFETY OF ACNE TREATMENT DEPENDING ON THE DOSE OF SYSTEMIC RETINOID

Authors:

Abstract:

Acne is a common dermatological disease that significantly affects the quality of life of young people during their period of greatest social activity. The purpose of the study was to evaluate the efficacy and safety of systemic retinoid therapy with different doses of isotretinoin in patients with moderate-to-severe acne, and to determine the frequency of relapse after treatment completion. 75 patients aged 16–35 years were examined and divided into three groups, each receiving isotretinoin at a dose of 0.3, 0.5, or 0.8 mg/kg. Increasing the daily dose accelerated the onset of the clinical effect and reduced the frequency of relapses, but was associated with an increase in adverse reactions, including retinoid xerosis, cheilitis, keratitis, dermatitis, and diffuse hair thinning. The optimal balance between efficacy and safety was observed with medium doses of isotretinoin. Extending the course of therapy until the target cumulative dose was achieved ensured sustained remission with minimal complications. The results emphasize the feasibility of individualized isotretinoin dose selection for acne treatment to optimize clinical outcomes and improve patients' quality of life.

Keywords:

acne isotretinoin systemic retinoids side effects acne recurrence dose dependence cumulative dose

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 77-81
УДК 616.53-002-085.263-036.8

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-77-81