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Clinical medicine

GENOTYPING OF FN1 AND VWF GENE POLYMORPHISMS IN PROGNOSIS, PREVENTION AND TREATMENT OF PERITONEAL ADHESION DISEASE

Published 2026-02-04

Authors:

S.B. Telemukha
Ivano-Frankivsk National Medical University image/svg+xml
https://orcid.org/0000-0001-9801-6219
O.V. Pyptiuk
Ivano-Frankivsk National Medical University image/svg+xml
https://orcid.org/0000-0003-0147-645X
Abstract:
Adhesion disease of the peritoneum is one of the difficult and unsolved problems of surgery. The polymorphism of the FN1 and VWF genes was detected by the cytogenetics method through the cultivation of peripheral blood leukocytes and the technology of preparing chromosomal preparations with differential methods of chromosome staining, and in the presence of the FN1 and VWF gene polymorphisms, the development was predicted adhesion disease. 45 patients were classified into 3 groups: 15 people who underwent planned surgery for incisional ventral hernias; 15 people who were urgently operated on for acute adhesion intestinal obstruction; 15 people who were not operated on the organs of the abdominal cavity. The analysis of the results of the examination of genetic factors in patients with different degrees of severity and prevalence of peritoneal adhesion disease in patients with acute adhesion intestinal obstruction indicates the presence of a relationship between the pronounced polymorphism of the FN1 and VWF genes and the severity of the manifestation of the adhesion disease syndrome. In the presence of chromosomal aberrations, corresponding biochemical disorders are observed.
Keywords:
Adhesive disease of the peritoneum acute adhesive intestinal obstruction polymorphism of the FN1 and VWF genes
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Publication:
«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 140-144
УДК 616-089;617.5, 616-084+616-037+616-089+616.381-007.274
DOI:
https://doi.org/10.26724/2079-8334-2026-1-95-140-144