EVALUATION OF LOCAL IMMUNE RESPONSE IN PREGNANT WOMEN WITH HUMAN PAPILLOMAVIRUS INFECTION

Authors:

Abstract:

This study investigated the impact of Human Papillomavirus infection on the local immune system during pregnancy. For this purpose, local immune responses – immunoglobulins and functional activity of neutrophils – in cervical secretions, were comparatively examined in three groups. Group I – 25 pregnant women with transient Human Papillomavirus infection, Group II – 24 pregnant women with persistent Human Papillomavirus infection, and a control group of 25 pregnant women without detected Human Papillomavirus infection. The results showed that, especially in cases of persistent Human Papillomavirus infection, although an increase in the total number of neutrophils in cervical mucus was observed, their phagocytic activity and functional capacity were significantly reduced. This is explained by the depletion of functional reserves of neutrophil cells due to the chronic course of the infection. At the same time, in persistent infections, the humoral immune response was found to be enhanced, with a statistically significant increase in IgG levels. This is interpreted as an indicator of the adaptive immune response developed against the prolonged presence of the virus in the body. The findings of this study demonstrate the potential diagnostic significance of local immune parameters – neutrophil activity and IgG levels – for predicting the clinical course and outcomes of Human Papillomavirus infection during pregnancy.

Keywords:

papillomavirus infection pregnant women immunoglobulins neutrophils

References:

1. Abu-Raya B, Michalski C, Sadarangani M, Lavoie PM. Maternal Immunological Adaptation During Normal Pregnancy. Front. Immunol. 2020;11:2627. doi: 10.3389/fimmu.2020.575197.
2. Aldhous MC, Bhatia R, Pollock R, Vragkos D, Cuschieri K, Cubie HA, et al HPV infection and pre-term birth: A data-linkage study using Scottish Health Data. Wellcome Open Res. 2019;4:48. doi: 10.12688/wellcomeopenres.15140.1.
3. Condrat CE, Filip L, Gherghe M, Cretoiu D, Suciu N. Maternal HPV Infection: Effects on Pregnancy Outcome. Viruses. 2021 Dec 7;13(12):2455. doi: 10.3390/v13122455.
4. Carlsen KCL, Granum B, Haugen G, Hedlin G, Hilde K, Nordlund B, et al. BMC Pregnancy Childbirth. 2024 Nov 19;24(1):764. doi: 10.1186/s12884-024-06958-2.
5. Ford JH, Li M, Scheil W, Roder D. Human papillomavirus infection and intrauterine growth restriction: A data-linkage study. J. Matern.-Fetal Neonatal Med. 2019;32:279–285. doi: 10.1080/14767058.2017.1378330.
6. Ismayilova SM. A modern approach to the management of pregnancy and childbirth in women infected with papillomavirus: PhD dissertation abstract in medical sciences. Baku, 2015: 6.
7. Niyibizi J, Zanré N, Mayrand M-H, Trottier H. Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis. J. Infect. Dis. 2020;221:1925–1937. doi: 10.1093/infdis/jiaa054.
8. Niyibizi J, Zanré N, Mayrand M-H, Trottier H. The association between adverse pregnancy outcomes and maternal human papillomavirus infection: A systematic review protocol. Syst. Rev. 2017;6:53. doi: 10.1186/s13643-017-0443-5.
9. Subramaniam A, Lees BF, Becker DA, Tang Y, Khan MJ, Edwards RK. Evaluation of Human Papillomavirus as a Risk Factor for Preterm Birth or Pregnancy-Related Hypertension. Obstet. Gynecol. 2016;127:233–240. doi: 10.1097/AOG.0000000000001247.
10. Værnesbranden MR, Staff AC, Wiik J, Sjøborg K, Rueegg CS, Sugulle M, et al. Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: a Scandinavian prospective mother-child cohort study. BMC Pregnancy Childbirth. 2024 Nov 19;24(1):764. doi: 10.1186/s12884-024-06958-2.
11. Værnesbranden MR, Wiik J, Sjøborg K, Staff AC, Carlsen KCL, Haugen G, et al. Maternal human papillomavirus infections at mid-pregnancy and delivery in a Scandinavian mother-child cohort study. Int. J. Infect. Dis. 2021;108:574–581. doi: 10.1016/j.ijid.2021.05.064.
12. World Health Organisation Human papillomavirus vaccines: WHO position paper, May 2017—Recommendations. Vaccine. 2017;35:5753–5755. doi: 10.1016/j.vaccine.2017.05.069.
13. Xiong YQ, Mo Y, Luo QM, Huo ST, He WQ, Chen Q. The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis. Gynecol. Obstet. Investig. 2018;83:417–427. doi: 10.1159/000482008.

Publication:

«World of Medicine and Biology» Vol. 21 No. 92 (2025) , с. 117-120
УДК 618.1‑006.52‑086.37

DOI:

https://doi.org/10.26724/2079-8334-2025-2-92-117-120