CONCURRENT TREATMENT OF CHILDREN’S EPILEPSY AND DEPRESSION

Authors:

Abstract:

Epileptic children suffer from depression, and this condition is not well diagnosed and treated, and this results in poor health. The purpose of this work is to evaluate the rate of depression in children with epilepsy and develop an integrated treatment plan. 156 children (aged 12–17 years) with epilepsy were evaluated for depression using Hamilton depression rating scale and the ICD–10 criteria. The current study establishes a high level of depression in children with epilepsy; 68 % of participants fulfilled the criteria for different degrees of depression. Out of the 106 patients diagnosed with depression, 83 had mild depression, 21 moderate and 2 had severe depression. Wilcoxon test showed significant reduction in depression severity after combined anticonvulsant and antidepressant treatment (p=0.048). This is especially important in children as the prevalence of epilepsy and depression is high, and both conditions should be treated concurrently. Depression in children with epilepsy should be diagnosed and treated as soon as possible to enhance neurological and psychiatric prognosis.

Keywords:

epilepsy depression children concurrent disease treatment

References:

1. Besag F, Aldenkamp A, Caplan R, Dunn DW, Gobbi G, Sillanpää M. Psychiatric and Behavioural Disorders in Children with Epilepsy: an ILAE Task Force Report. Epileptic Disord. 2016 May;18 Suppl 1:1–86. English. doi: 10.1684/epd.2016.0809.
2. Fiest KM, Patten SB, Jette N, Wiebe S. Systematic review and meta-analysis of the association between mood disorders and epilepsy. Epilepsy Research. 2014; 108(6), 998–1004.
3. Kanner AM. Depression and epilepsy: A new perspective on two closely related disorders. Epilepsy & Behavior, 2016;61:199–203.
4. Kieling C, Buchweitz C, Caye A, Silvani J, Ameis SH, Brunoni AR, et al. Worldwide Prevalence and Disability From Mental Disorders Across Childhood and Adolescence: Evidence From the Global Burden of Disease Study. JAMA Psychiatry. 2024 Apr 1;81(4):347–356. doi: 10.1001/jamapsychiatry.2023.5051.
5. Kwong KL, Lam D, Tsui S, Ngan M, Tsang B, Lai TS, et al. Anxiety and Depression in Adolescents With Epilepsy. J Child Neurol. 2016 Feb;31(2):203–10. doi: 10.1177/0883073815587942.
6. LaGrant B, Marquis BO, Berg AT, Grinspan ZM. Depression and anxiety in children with epilepsy and other chronic health conditions: National estimates of prevalence and risk factors. Epilepsy Behav. 2020 Feb;103(Pt A):106828. doi: 10.1016/j.yebeh.2019.106828.
7. Lu JP, Cao XL. Children with epilepsy suffer from depression or anxiety. Chin Pract J Pediatr 2017; 32:266–9.
8. Mula M. Epilepsy and depression: An update. *Archives of Medical and Health Sciences*. 2019; 7(1), 104–111.
9. Mula M, Sander, JW. Psychopharmacology in patients with epilepsy: A review of new treatments. Current Opinion in Psychiatry. 2017; 30(3), 201–206.
10. Operto FF, Pastorino GMG, Pippa F, Padovano C, Vivenzio V, Scuoppo C, et al. Psychiatric Symptoms and Parental Stress in Children and Adolescents With Epilepsy. Front Neurol. 2021 Dec 8; 12:778410. doi: 10.3389/fneur.2021.778410.
11. Scott AJ, Sharpe L, Loomes M, Gandy M. Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy. J Pediatr Psychol. 2020 Mar 1;45(2):133–144. doi: 10.1093/jpepsy/jsz099.
12. WHO: https://www.who.int/ru/news-room/fact-sheets/detail/epilepsy Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Lancet Neurol 2019; Volume 18; ISSUE 5; P. 357–375. DOI: https://doi.org/10.1016/S1474-4422(19)301206.
13. Yang C, Hao Z, Mao Y, Xu Q, Zhao L, Zhang LL. Depression in children with epilepsy from western China: A cross-sectional survey. Medicine (Baltimore). 2020 Jun 12;99(24):e20647. doi: 10.1097/MD.0000000000020647.

Publication:

«World of Medicine and Biology» Vol. 20 No. 90 (2024) , с. 11-14
УДК 616.853:616.89–008

DOI:

https://doi.org/10.26724/2079-8334-2024-4-90-11-14