Clinical medicine
DISCRIMINANT MODELS OF THE LIKELIHOOD AND CHARACTERISTICS OF MULTIPLE SCLEROSIS PROGRESSION IN UKRAINIAN MEN DEPENDING ON BODY SIZE PARAMETERS
Published
2024-10-16
Authors:
MG
M.М. Gunas
GM
G.S. Moskovko
IR
I.A. Rutska
GG
G.M. Galunko
TA
T.V. Antoniuk
- Abstract:
-
In young Ukrainian men, based on the characteristics of body size, reliable discriminant models were built, which allow with high probability (correctness of the classification matrix 100 % of cases, Wilks' Lambda statistics=0.051, p<0.0001) to attribute the studied subjects to “typical” for practically healthy people or the general group of patients with multiple sclerosis. Based on the characteristics of body size between multiple sclerosis men with mild (EDSS 1.5–2.0) and moderate (EDSS 3.5–4.5) disorders, a reliable interpretation of the obtained classification indicators is also possible with medium probability (correctness of the classification matrix 96.8 % of cases, Wilks' Lambda statistics=0.342, p<0.0001).
- Keywords:
-
nervous diseases multiple sclerosis anthropometric indicators discriminant models practically healthy and sick men
- References:
-
- Fedonyuk YaІ, Dubinin SІ. Medychna biolohiya, anatomiya, fiziolohiya ta patolohiya liudyny. Navchalnyi posibnyk. Vinnytsia: Nova Knyga, 2010. [in Ukrainian].
- Almramhi MM, Storm CS, Kia DA, Coneys R, Chhatwal BK, Wood NW. The role of body fat in multiple sclerosis susceptibility and severity: A Mendelian randomisation study. Multiple Sclerosis Journal. 2022 Oct;28(11):1673–84. doi: 10.1177/13524585221092644.
- Charron S, McKay KA, Tremlett H. Physical activity and disability outcomes in multiple sclerosis: A systematic review (2011–2016). Multiple sclerosis and related disorders. 2018 Feb 1; 20:169–77. doi: 10.1016/j.msard.2018.01.021.
- Dardiotis E, Tsouris Z, Aslanidou P, Aloizou AM, Sokratous M, Provatas A, et al. Body mass index in patients with Multiple Sclerosis: a meta-analysis. Neurological Research. 2019 Sep 2;41(9):836–46. doi: 10.1080/01616412.2019.1622873.
- Dobson R, Giovannoni G. Multiple sclerosis – a review. European journal of neurology. 2019 Jan;26(1):27–40. doi: 10.1111/ene.13819.
- Drehmer E, Platero JL, Carrera-Juliá S, Moreno ML, Tvarijonaviciute A, Navarro MÁ, et al. The relation between eating habits and abdominal fat, anthropometry, PON1 and IL-6 levels in patients with multiple sclerosis. Nutrients. 2020 Mar 11;12(3):744. doi: 10.3390/nu12030744.
- Fitzgerald KC, Salter A, Tyry T, Fox RJ, Cutter G, Marrie RA. Measures of general and abdominal obesity and disability severity in a large population of people with multiple sclerosis. Multiple Sclerosis Journal. 2020 Jul;26(8):976–86. doi: 10.1177/1352458519845836.
- Giannopapas V, Stefanou MI, Smyrni V, Kitsos DK, Kosmidou M, Stasi S, et al. Waist Circumference and Body Mass Index as Predictors of Disability Progression in Multiple Sclerosis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2024 Mar 18;13(6):1739. doi: 10.3390/jcm13061739.
- Gil-González I, Martín-Rodríguez A, Conrad R, Pérez-San-Gregorio MÁ. Quality of life in adults with multiple sclerosis: a systematic review. BMJ open. 2020 Nov 1;10(11): e041249. doi: 10.1136/bmjopen-2020-041249.
- Leray E, Moreau T, Fromont A, Edan G. Epidemiology of multiple sclerosis. Revue neurologique. 2016 Jan 1;172(1):3–13. doi: 10.1016/j.neurol.2015.10.006.
- Lutfullin I, Eveslage M, Bittner S, Antony G, Flaskamp M, Luessi F, et al. Association of obesity with disease outcome in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2023 Jan 1;94(1):57–61. doi: 10.1136/jnnp-2022-329685.
- Misicka E, Gunzler D, Albert J, Briggs FB. Characterizing causal relationships of visceral fat and body shape on multiple sclerosis risk. Multiple Sclerosis and Related Disorders. 2023 Nov 1; 79:104964. doi: 10.1016/j.msard.2023.104964.
- Sawcer S, Franklin RJ, Ban M. Multiple sclerosis genetics. The Lancet Neurology. 2014 Jul 1;13(7):700–9. doi: 10.1016/S1474-4422(14)70041-9.
- Wesnes K, Riise T, Casetta I, Drulovic J, Granieri E, Holmøy T, et al. Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Multiple Sclerosis Journal. 2015 Apr;21(4):388–95. doi: 10.1177/1352458514546785.
- Yuan S, Xiong Y, Larsson SC. An atlas on risk factors for multiple sclerosis: a Mendelian randomization study. Journal of neurology. 2021 Jan; 268:114–24. doi: 10.1007/s00415-020-10119-8.
- Publication:
-
«World of Medicine and Biology»
Vol. 20 No. 90 (2024)
, с. 34-38
УДК 616.832:572.087
How to Cite
DISCRIMINANT MODELS OF THE LIKELIHOOD AND CHARACTERISTICS OF MULTIPLE SCLEROSIS PROGRESSION IN UKRAINIAN MEN DEPENDING ON BODY SIZE PARAMETERS. (2024). World of Medicine and Biology, 20(90), 34-38. https://doi.org/10.26724/2079-8334-2024-4-90-34-38
Share

English
Ukrainian