GENETIC POLYMORPHISMS AS A RISK FACTOR FOR TYPE 1 DIABETES MELLITUS AND ORAL DISEASES

Authors:

Abstract:

The study analyzed the association between toll-like receptor-2 (TLR2 rs5743708 Arg753Gln), interleukin-10 (IL-10 rs3024491 G-1082A), vitamin D receptor (VDR rs1544410 283A/G(BsmI), osteopontin (OPN rs1126616 C6982T) of single nucleotide polymorphisms and the type 1 diabetes, oral diseases susceptibility in the Ukrainian children. The study included 27 children divided into two groups (17 children with type 1 diabetes and 10 children without concomitant diseases). The state of oral health was assessed according to generally accepted methods. As a result of the studies, it was found that IL-10 gene polymorphism was associated with the risk of the type 1 diabetes in the heterozygous and mutant alleles. In the dominant GG allele, IL-10 significantly reduces the risk of the the type 1 diabetes (OR=5.05, 95% CI, 1.79–221.62, P=0.004). No significant differences were found in the frequency of genotypes of the genes for the toll-like receptor-2 (TLR2 rs5743708 Arg753Gln), vitamin D receptor (VDR rs1544410 283A/G (BsmI), osteopontin (OPN rs1126616 C6982T) and variations in their alleles in groups. The study of the association between gene polymorphism and the main indicators of oral health in children did not demonstrate any statistically significant indices.

Keywords:

oral health caries periodontitis type 1 diabetes mellitus children genetic polymorphism

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Publication:

«World of Medicine and Biology» Vol. 20 No. 90 (2024) , с. 98-102
УДК 616.31; 617.52-089; 616-053.5]:575.117.2

DOI:

https://doi.org/10.26724/2079-8334-2024-4-90-98-102