MECHANISMS OF ENDOMETRIAL HYPERPLASIA DEVELOPMENT IN WOMEN OF REPRODUCTIVE AGE

Authors:

Abstract:

Data from studies of 88 women were examined during a diagnostic endometrial biopsy for abnormal uterine bleeding or increased endometrial thickness. The patients were between 40 and 55 and divided into the main and control groups. A high expression of estrogen-α receptors and a low expression of progesterone hormones were found, indicating proteins' pro-oncogenicity in patients with complex endometrial hyperplasia. Pathogenetic mechanisms of endometrial hyperplasia were factors of proliferation and apoptosis, which is confirmed by a significant increase in the proliferation marker Ki67 of epithelial cells in complex endometrial hyperplasia in endometrial biopsies and a decrease in the apoptosis marker p53. A differentiated approach to diagnosing endometrial hyperplasia is based on the determination of molecular markers (Ki67, p53), which allows one to predict the course of the hyperplastic process and assess the effectiveness of the treatment.

Keywords:

endometrial hyperplasia morphological features hormonal status therapeutic tactics expression of estrogen and progesterone receptors molecular markers

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Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 74-79
УДК 618.145-007.415-091.8-078.33

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-74-79