PREDICTIVE VALUE OF INFLAMMATORY CYTOKINES IN PREDICTING THE RISK OF PROLIFERATIVE DIABETIC RETINOPATHY

Authors:

Abstract:

A retrospective clinical and immunological study determined the diagnostic value of inflammatory cytokines in predicting the development of proliferative diabetic retinopathy. 82 patients with diabetes mellitus were divided into two groups: group 1 – 40 patients without developing proliferative complications of diabetic retinopathy and group 2 – 42 patients with the transition of non-proliferative diabetic retinopathy to proliferative one. In the blood of patients of the second group, there was a significantly higher level of concentration of the cytokines TNF-α (Pu=0.001), IL-1β (Pu<0.001), IL-8 (Pu<0.001) in the absence of significant changes in the cytokine IL-4 (Pu=0.094; Pu=0.073). The distribution of the balance of cytokines towards pro-inflammatory ones indicates the critical role of systemic inflammation along the type 1 T-helper pathway in the pathogenesis of proliferative diabetic retinopathy. The values of TNF-α cytokines above the level of 6.3 pg/ml (test sensitivity 71.4 %, specificity 65.0 %), IL-1β above 11 pg/ml (test sensitivity 69.0 %, specificity 87.5 %), IL-8 above 28 pg/ml (test sensitivity 81.0 %, specificity 65.0 %) can be used as criteria for predicting a high risk of developing proliferative diabetic retinopathy.

Keywords:

diabetic retinopathy tumor necrosis factor-α interleukin-1ß interleukin-8 interleukin-4 prognosis criteria inflammation

References:

1. Ivanchenko AYu, Bezkorovayna IM. Doslidzhennya zmin mikrotsyrkulyatsiyi sitkivky pislya rehmatohennoho vidsharuvannya sitkivky bez vidsharuvannya makulyarnoyi zony ta z vidsharuvannyam makulyarnoyi zony za danymy optychnoyi koherentnoyi tomohrafiyi – anhiohrafiyi: prospektyvne doslidzhennya. Aktualni problemy suchasnoyi medytsyny: Visnyk Ukrayinskoyi medychnoyi stomatolohichnoyi akademiyi. 2021; 4 (76): 33–37. doi: 10.31718/2077–1096.21.4.33. [in Ukrainian].
2. Serdyuk VN, Pilipenko LYu. Porivnyalna otsinka vplyvu faktoriv prohresuvannya diabetychnoyi retynopatiyi na vmist markera poshkodzhennya endoteliyu interleykinu-8 u krovi pry metabolichnomu syndromi. Oftalmolohiya. 2017; 2(07) doi: 10.30702/Ophthalmology.2017/07.art7. [in Ukrainian].
3. Bromberg-White JL, Glazer L, Downer R, Furge K, Boguslawski E, Duesbery NS. Identification of VEGF-independent cytokines in proliferative diabetic retinopathy vitreous. Invest. Ophthalmol. Vis. Sci. 2013; 54(10): 6472–6480. doi: 10.1167/iovs.13-12518.
4. Cao YL, Zhang FQ, Hao FQ. Th1/Th2 cytokine expression in diabetic retinopathy. Genet Mol Res. 2016; 15(3). doi: 10.4238/gmr.15037311.
5. Capitão M, Soares R. Angiogenesis and inflammation crosstalk in diabetic retinopathy. J Cell Biochem. 2016; 117(11): 2443–2453. doi: 10.1002/jcb.25575.
6. Hang H, Yuan S, Yang Q, Yuan D, Liu Q. Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy. Mol Vis. 2014; 20: 1137–1145.
7. Hernandez-Da Mota SE, Soto-Bahena JJ, Viveros-Sandoval ME, Cardiel-Rios M. Pro-inflammatory serum cytokines in diabetic retinopathy. Cir Cir. 2015; 83(2): 100–106. doi: 10.1016/j.circir.2015.04.003.
8. Leley SP, Ciulla TA, Bhatwadekar AD. Diabetic retinopathy in the aging population: a perspective of pathogenesis and treatment. Clin Interv Aging. 2021; Jul 15(16): 1367–1378. doi: 10.2147/CIA.S297494.
9. Li H, Liu X, Zhong H, Fang J, Li X, Shi R, Yu Q. Research progress on the pathogenesis of diabetic retinopathy. BMC Ophthalmol. 2023; Sep 11; 23(1): 372. doi: 10.1186/s12886-023-03118-6.
10. Majidova SR. Evaluation of the role of the relationship of inflammatory cytokines with the neoangiogenesis factor in the development of proliferative diabetic retinopathy. World of Medicine and Biology. 2023; 3 (85): 148–152. doi: 10.26724/2079-8334-2023-3-85-148-152.
11. McAuley AK, Sanfilippo PG, Hewitt AW, Liang H, Lamoureux E, Wang JJ et al. Vitreous biomarkers in diabetic retinopathy: a systematic review and meta-analysis. J. Diabetes Complications. 2014; 28(3): 419–425. doi: 10.1016/j.jdiacomp.2013.09.010.
12. Pera-Vasylchenko AV, Ryadnova VV, Voskresenska LK, Bezkorovayna IM, Bezega НМ. Pathomorphological changes of the optical nerve intracranial part in diabetes mellitus. World of Medicine and Biology. 2021; 1(75): 201–205. doi: 10.26724/2079–8334–2021–1–75–201–205.
13. Tan TE, Wong TY. Diabetic retinopathy: looking forward to 2030. Front Endocrinol (Lausanne). 2023; Jan 9 (13): 1077669. doi: 10.3389/fendo.2022.1077669.
14. Virgili G, Parravano M, Evans JR, Gordon I, Lucenteforte E. Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis. Cochrane Database Syst Rev. 2018; Oct 16; 10(10): CD007419. doi: 10.1002/14651858.CD007419. pub6.
15. Youngblood H, Robinson R, Sharma A, Sharma S. Proteomic biomarkers of retinal inflammation in diabetic retinopathy. Int J Mol Sci. 2019; Sep 25; 20(19): 4755. doi: 10.3390/ijms20194755.

Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 135-140
УДК [617.735-002-02:616.379-008.64]:616-079.7

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-135-140