HISTOLOGICAL AND MICROBIOLOGICAL RATIONALE FOR THE USE OF MATRIX MATERIALS IMPREGNATED WITH ANTIBIOTICS FOR THE RECONSTRUCTION OF BONE TISSUE DEFECTS

Authors:

Abstract:

Studying the combination of fibrous scaffold materials with therapeutic agents as a drug delivery system is important for regenerative medicine. The results of the antibiotic-absorbing capacity of the fibrous non-woven polycaprolactone matrices created by us, as well as their influence on the regeneration of bone tissue, were analyzed in the study. The results of microbiological studies indicated the pronounced hydrophilic properties of the matrices we’ve created; it was confirmed by a decrease in the activity of the antibiotic only at 16.4 % after 7 days (р<0.05). Instead, in an experiment on laboratory animals, the specified frame effect of fibers was confirmed by the beginning of the formation of an organized bone structure, namely, by an increase in osteoid up to 34.38 % (p<0.05), at an early stage so far.

Keywords:

matrix materials polycaprolactone antibiotic impregnation cefazolin lincomycin histological analysis bone tissue

References:

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Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 220-224
УДК 606:61+579+616-092.9+ 616-089

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-220-224