ALPHA-1-ANTITRYPSIN – A BIOMARKER OF ANTIPROTEASE PROTECTION IN THE PREDICTION OF PREMATURE BIRTH IN COVID-19 AND HEALTHY PREGNANT WOMEN

Authors:

Abstract:

Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality worldwide. This problem has become especially relevant in the COVID-19 era. The purpose of the study was to investigate the association between serum alpha-1-antitrypsin levels and premature birth in COVID-19 and healthy pregnant women. Our study showed that serum alpha- 1-antitrypsin levels increase during normal pregnancy. We found that changes in alpha-1-antitrypsin concentrations are an important factor in preterm birth. Namely, there is an inverse relationship between alpha-1 antitrypsin levels and preterm birth: the lower the serum alpha-1 antitrypsin level, the higher the risk of preterm birth. In this study, we found that non-pregnant women with COVID-19 had a lower of alpha-1-antitrypsin levels then healthy non-pregnant women. In group pregnant women with COVID-19 with preterm birth level of α1-AT was approximately 1.5-fold lower in pregnant women with COVID-19 with timely delivery.

Keywords:

alpha-1-antitrypsin preterm birth COVID-19

References:

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Publication:

«World of Medicine and Biology» Vol. 19 No. 86 (2023) , с. 86-91
УДК 616.61-006:616.65+576.367

DOI:

https://doi.org/10.26724/2079-8334-2023-4-86-86-91