ULTRASTRUCTURAL CHANGES IN THE VESSELS OF THE LUNG MICROCIRCULATORY BED IN CORONAVIRUS INFECTION

Authors:

Abstract:

Damage to the endothelium of pulmonary microcirculatory vessels and the development of coagulopathy are considered important elements of the pathogenesis of coronavirus infection. The purpose of the study was to determine the ultrastructural changes of the microcirculatory bed of the lungs of patients who died due to respiratory failure during the coronavirus infection, using transmission electron microscopy. In the vessels of the microcirculatory bed of the lungs of patients who died on the 14th, 20th, 22nd, and 40th days of the disease, dyscirculatory processes of varying severity were observed in the form of severe hyperemia, stasis, microthrombi, and alternative changes in the endothelium. Damage to the vessels of the microcirculatory bed was accompanied by pronounced coagulopathy and endotheliitis, which are key aspects of the pathogenesis and thanatogenesis of coronavirus infection.

Keywords:

coronavirus infection COVID-19 transmission electron microscopy pulmonary microcirculatory bed endothelium coagulopathy

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Publication:

«World of Medicine and Biology» Vol. 19 No. 86 (2023) , с. 92-97
УДК 611.24:616.16]-092:578.834.1]-076.4

DOI:

https://doi.org/10.26724/2079-8334-2023-4-86-92-97