SPHINGOSINE-1-PHOSPHATE AS A NEW DIAGNOSTIC, PROGNOSTIC BIOMARKER FOR PROSTATE CANCER AND EFFECTIVENESS OF INTENSITY-MODULATED RADIATION THERAPY

Authors:

Abstract:

Sphingosine-1-phosphate have long been implicated in different biological processes including cell migration, proliferation, and cell death. Our hypothesis is based on the possible role of sphingosine-1-phosphate as a biomarker of poor prognosis in prostate cancer and effectiveness of intensity-modulated radiation therapy. The Tomo System there were treated 41 patients with locally advanced cancer prostate. To determine free sphingosine, we used a method based on the extraction of sphingoid bases with diethyl ether, in our modification. The levels of normal tissue sphingosine-1-phosphate are significantly higher as compared with prostate cancer. There is a significant correlation between plasma prostate-specific antigen and tumor tissue sphingosine-1-phosphate in prostate cancer. Sphingosine-1-phosphate is synthesized in the tumor tissue of prostate cancer 2-fold less than in the surrounding tumor tissue. After radiation therapy, its level in the prostate tumor increases 3-fold, and in the tissue surrounding the tumor 1.5-fold, which indicates the development of the radiation-induced bystander effect. Our data provide the first evidence that tumor tissue sphingosine-1-phosphate is a significant prognostic marker for prostate cancer mortality.

Keywords:

sphingosine-1-phosphate prostate cancer radiation therapy

References:

1. Komarevtseva ІO, Chebotarova AA. Vplyv zastosuvannya apoptoz-іndukovanykh mezenkhіmalnykh stovburovykh klіtyn na rіven fragmentatsіyi DNK і aktyvnіst systemy sfіngozynu v umovakh eksperymentalnoho modelyuvannya patolohіchnoho protsesu. Medychna ta klіnіchna khіmіya. 2016. 18(1): 19–23.
2. Agrawal R, Dey A, Datta S. Pattern of Radiotherapy Treatment in Low-Risk, Intermediate-Risk, and High-Risk Prostate Cancer Patients: Analysis of National Cancer Database. Cancers (Basel). 2022; 14(22). doi:10.3390/cancers14225503
3. Cheng JC, Bai A, Beckham TH. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest. 2013;123(10):4344–4358. doi:10.1172/JCI64791
4. Cozzi S, Ruggieri MP, Alì E. Moderately Hypofractionated Helical Tomotherapy for Prostate Cancer: Ten-year Experience of a Mono-institutional Series of 415 Patients. In Vivo. 2023;37(2):777–785. doi:10.21873/invivo.13141
5. Hara D, Tao W, Schmidt RM. Boosted Radiation Bystander Effect of PSMA-Targeted Gold Nanoparticles in Prostate Cancer Radiosensitization. Nanomaterials. 2022;12(24). doi:10.3390/nano12244440
6. Janneh AH, Kassir MF, Dwyer CJ, Chakraborty P, Pierce JS, Flume PA, et al. Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients. Sci. Rep. 2021;11:14232. doi: 10.1038/s41598-021-93857-7.
7. Janneh AH and Ogretmen B. Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment. Cancers (Basel). 2022 May; 14(9): 2183. doi: 10.3390/cancers14092183
8. Moradi S, Hashemi B, Bakhshandeh M, Banaei A, Mofid B. Introducing new plan evaluation indices for prostate dose painting IMRT plans based on apparent diffusion coefficient images. Radiat Oncol. 2022;17(1). doi:10.1186/s13014-022-02163-7
9. Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, et. al. Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. J Mammary Gland Biol Neoplasia. 2016 Jun; 21(1-2): 9–17. doi: 10.1007/s10911-016-9354-7
10. Ni J, Bucci J, Malouf D, Knox M, Graham P, Li Y. Exosomes in Cancer Radioresistance. Front Oncol. 2019;9. doi:10.3389/fonc.2019.00869
11. Nunes J, Naymark M, Sauer L. Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. Br J Cancer. 2012;106(5):909-915. doi:10.1038/bjc.2012.14
12. Pustovoit GL, Sarychev, LP, Savchenko RB, Sarychev YV, Ustenko RI, Sukhomlin SA. Anticholinergic burden in aging patients and its role in the development of bladder decompensation. World of Medicine and Biology. 2022; 81(3): 138–142.
13. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660.
14. Wu Y, Liu Y, Gulbins E, Grassmé H. The Anti-Infectious Role of Sphingosine in Microbial Diseases. Cells. 2021;10:1105. doi: 10.3390/cells10051105.
15. Zhang F, Wang L, Li Y. Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells. Stem Cell Res Ther. 2017;8(1):1-15. doi:10.1186/s13287-016-0455-4

Publication:

«World of Medicine and Biology» Vol. 19 No. 84 (2023) , с. 93-98
УДК 616.61-006:616.65+576.367

DOI:

https://doi.org/10.26724/2079-8334-2023-2-84-93-98