QUALITY OF LIFE IN CHRONIC PANCREATITIS WITH ACCOMPANYING ARTERIAL HYPERTENSION IN AGE ASPECT AND ITS RELATIONSHIP WITH MALNUTRITION MARKERS

Authors:

Abstract:

The problem of quality of life in chronic pancreatitis remains to be actual. The presence of comorbid pathology in chronic pancreatitis can be an aggravating factor for the quality of life and malnutrition manifestations. 110 patients were included. Standardized questionnaires were used (SF-36, GSRS). The levels of total protein, serum albumin, serum iron and vitamin D, serum zinc and magnesium levels were determined. A significant decrease in quality of life was proven in the group of patients with chronic pancreatitis and hypertension. Significantly lower indicators of psychological health and role functioning were noted among the 45–55-year-old group, and among patients 56–65 years had significantly lower indicators of physical functioning, role-based physical functioning, vitality and social functioning, which correlated with markers of malnutrition. The level of total protein, albumin, vitamin D, and iron in blood serum can be markers of malnutrition in patients with chronic pancreatitis combined with hypertension.

Keywords:

quality of life chronic pancreatitis arterial hypertension malnutrition biomarkers

References:

1. Amann ST, Yadav D, Barmada MM, O'Connell M, Kennard ED, Anderson M, et al. Physical and mental quality of life in chronic pancreatitis: a case-control study from the North American Pancreatitis Study 2 cohort. Pancreas. 2013; 42(2) :293–300. doi: 10.1097/MPA.0b013e31826532e7.
2. Arvanitakis M, Ockenga J, Bezmarevic M, Gianotti L, Krznariæ Ž, Lobo DN, et al. ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clin Nutr. 2020; 39 :612–31. doi: 10.1016/j.clnu.2020.01.004
3. Bang UC, Benfield T, Hyldstrup L, Bendtsen F, Beck Jensen JE. Mortality, cancer, and comorbidities associated with chronic pancreatitis: a Danish nationwide matched-cohort study. Gastroenterology. 2014; 146(4) :989–94. doi: 10.1053/j.gastro.2013.12.033.
4. de van der Schueren MAE, Keller H, Cederholm T, Barazzoni R, Compher C, Correia MITD, et al. Global Leadership Initiative on Malnutrition (GLIM): Guidance on validation of the operational criteria for the diagnosis of protein-energy malnutrition in adults. Clin Nutr. 2020; 39(9) :2872–2880. doi: 10.1016/j.clnu.2019.12.022.
5. Feshchenko Yu, Mostovoy Yu, Babiychuk Yu. The procedure for adapting the international questionnaire for assessing the quality of life of the Ministry of Education and Culture SF-36 in Ukraine. Experience of use in patients with bronchial asthma. Ukrainian pulmonology journal. 2002; 3: 9–11.
6. Filippova A, Löhr M, Kryvoshei V. Blood lipid spectrum and elastic properties of arteries in patients with chronic pancreatitis in combination with arterial hypertension. Medychni perspektyvy. 2022; 27 (1) :42–49.
7. Löhr JM, Dominguez-Munoz E, Rosendahl J, Besselink M, Mayerle J, Lerch MM, et al. United European gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). United European Gastroenterol J. 2017; 5 :153–99. doi: 10.1177/2050640616684695
8. Min M, Patel B, Han S, Bocelli L, Kheder J, Vaze A, et al. Exocrine pancreatic insufficiency and malnutrition in chronic pancreatitis: identification, treatment, and consequences. Pancreas. 2018; 47:1015–8. doi: 10.1097/MPA.0000000000001137
9. Ouyang G, Pan G, Liu Q, Wu Y, Liu Z, Lu W, Li S, Zhou Z, Wen Y. The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. BMC Med. 2020; 18(1):388. doi: 10.1186/s12916-020-01859-5.
10. Spagnolo DM, Greer PJ, Ohlsen CS, Mance S, Ellison M, Breze C, et al. Acute and Chronic Pancreatitis Disease Prevalence, Classification, and Comorbidities: A Cohort Study of the UK BioBank. Clin Transl Gastroenterol. 2022; 13(1): e00455. doi: 10.14309/ctg.0000000000000455.
11. Stepanov Yu, Filippova A. Dyslipidemia in patients with non-alcoholic hepatic steatohepatitis and biliary pathology and ways of its correction. Modern gastroenterology. 2010; 4(54):46–51.
12. Wiese ML, Aghdassi AA, Lerch MM, Steveling A. Excess Body Weight and Pancreatic Disease. Visc Med. 2021; 37(4):281–286. doi: 10.1159/000517147.
13. Wiese ML, Gärtner S, von Essen N, Doller J, Frost F, Tran QT, et al. Malnutrition Is Highly Prevalent in Patients with Chronic Pancreatitis and Characterized by Loss of Skeletal Muscle Mass but Absence of Impaired Physical Function. Front Nutr. 2022; 9:889489. doi: 10.3389/fnut.2022.889489.
14. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018; 39(33):3021–3104. doi: 10.1093/eurheartj/ehy339.
15. Zhdan VN, Tkachenko MV, Kitura YeM, Babanina MYu, Kyrian OA. Osteoarthritis and metabolic syndrome: unity of pathogenetic mechanisms. World of medicine and biology. 2021; 4 (78): 56–60.

Publication:

«World of Medicine and Biology» Vol. 19 No. 84 (2023) , с. 158-162
УДК 616.37-002.2-008.6:613.2:616.12-008.331.1]-053-092.11

DOI:

https://doi.org/10.26724/2079-8334-2023-2-84-158-162