OXIDATIVE STRESS IN LIVER TISSUES AT ALCOHOLIC HEPATITIS AND ITS CORRECTION BY A COMPLEX COMPOUND SYNTHESIZED ON THE BASIS OF PALLADIUM AND MEXIDOL

Authors:

Abstract:

An experiment was conducted on 20 white rats bred in vivarium conditions at the Research Center of the Azerbaijan Medical University, and divided into 4 groups. The 1st group included intact experimental animals, the 2nd-4th groups – experimental animals simulating alcoholic hepatitis. A complex compound (mexidazole) synthesized on the basis of palladium and mexidol was injected into the abdominal cavity of group 3 animals for 3 days, and group 4 animals – for 7 days at a dose of 0.02 mg/kg. A model of alcoholic hepatitis has been developed. In the homogenate, the average concentrations of surface-located SH-groups, internal protein-SH-groups, peroxidase, catalase and total antioxidant activity decreased compared to the intact state. In the blood of experimental animals, due to the action of alcohol, the activity of liver enzymes significantly increased, free lipid peroxidation increased in the liver tissue. The body's antioxidant defense system has significantly weakened. The results of the 3rd group of experimental animals showed that oxidative stress in the liver continues even after 10 days since the creation of the alcoholic hepatitis model. After injection of 0.02 mg/kg of mexidozole into the abdominal cavity for 3 days, the concentration of these enzymes in the blood tended to decrease. After daily administration of mexidozole at a dose of 0.02 mg/kg for 3 days into the abdominal cavity of white rats against the background of an alcoholic hepatitis model, pronounced positive changes in the dynamics of oxidative stress were noted.

Keywords:

alcohol hepatitis enzymes oxidative stress palladium and mexidol

References:

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Publication:

«World of Medicine and Biology» Vol. 19 No. 84 (2023) , с. 180-185
УДК 616-003.72; 619: 616.36-002: 615

DOI:

https://doi.org/10.26724/2079-8334-2023-2-84-180-185