MEXIDOL AND VORTIOXETINE ADMINISTRATION ENCOURAGING RESULTS IN EXPERIMENTAL POST-STROKE DEPRESSION COMPLEX TREATMENT

Authors:

Abstract:

The purpose of the study was to investigate the efficacy of combined mexidol and vortioxetine administration in conditions of experimental chronic brain ischemia. 65 rats were randomized into 5 groups, respectively, due to induced chronic brain ischemia and its correction using mexidol and vortioxetine separate and combined administration. The neurological deficits expression, the ability to form the conditioned reflexes of active avoidance, short-term and long-term memory keeping as well as the aggressive-defensive behaviour were studied in rats throughout the post-ischemic period. 1 day of the trial revealed immobility and neurological deficit in rats accompanied by cognitive disorders and the emotional behaviour disturbance. An expressed anti-ischemic effect in the case of simultaneous mexidol endonasal administration and vortioxetine systemic was shown. Both mexidol and vortioxetine combined administration was proved to make a significant contribution to neurological deficits recovery, the memory disorders elimination and the aggressive-protective behaviour normalization in animals during the post-ischemic state. The authors considered that the positive results of the effective use of mexidol and the multimodal antidepressant vortioxetine which are manifested by neurological deficits and mnestic functions restoration together with the emotional sphere normalization in ischemic conditions allow to recommend these compounds use in functional disorders complex correction in patients with ischemic strokes at the rehabilitation stage.

Keywords:

stroke post-stroke depression motor deficit cognitive impairment mexidol vortioxetine pathophysiological mechanisms rehabilitation

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Publication:

«World of Medicine and Biology» Vol. 19 No. 84 (2023) , с. 203-208
УДК 616.831-007.17:616-036.838:616.89-008.454]-092+557.146.1

DOI:

https://doi.org/10.26724/2079-8334-2023-2-84-203-208