PATHOMORPHOLOGICAL CHANGES OF THE LUNGS OF MATURE MALE RATS IN CONDITIONS OF EXPERIMENTAL OBESITY AND TOBACCO SMOKING

Authors:

Abstract:

The influence of obesity (with and without passive smoking) on the formation of pathomorphological changes in the lungs was studied in 4 groups of sexually mature male rats: the control group (CL), the group with isolated alimentary obesity (O), the group exposed to isolated exposure to tobacco smoke (S), the group with combined dietary obesity and exposure to tobacco smoke (OS) after 4 months of the experiment. The morphological changes found in the CL group were insignificant. In group S, the presence of changes characteristic of chronic bronchitis and focal emphysema was established. Pathomorphological changes typical for the chronic obstructive pulmonary disease were found in group O: chronic bronchitis, initial manifestations of bronchiectasis formation, pulmonary emphysema, focal pneumosclerosis, and initial manifestations of pulmonary hypertension. In the OS group, the changes were not qualitatively different from those in the O group. It was found that the changes characteristic of chronic obstructive pulmonary disease developed in rats with simulated obesity, regardless of whether the smoking model was used.

Keywords:

experimental obesity smoking rats pathomorphological changes in the lungs

References:

1. Aghaloo T, Kim JJ, Gordon T, Behrsing HP. In Vitro Models, Standards, and Experimental Methods for Tobacco Products. Adv Dent Res. 2019 Oct;30(1):16–21. doi: 10.1177/0022034519872474.
2. Baffi CW, Wood L, Winnica D, Strollo PJ Jr, Gladwin MT, Que LG, et al. Metabolic Syndrome and the Lung. Chest. 2016;149: 1525–1534. pmid:26836925
3. CCAC guidelines on: euthanasia of animals used in science. Ottawa: Canadian Council on Animal Care, Cop; 2010.
4. Conn PM. Animal Models for the Study of Human Disease. Animal Models for the Study of Human Disease. Elsevier Inc.; 2013. 1–1089 p.
5. Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev Respir Med. 2018 Sep;12(9):755–767. doi: 10.1080/17476348.2018.1506331.
6. Fuller-Thomson E, Howden KEN, Fuller-Thomson LR, Agbeyaka S. A Strong Graded Relationship between Level of Obesity and COPD: Findings from a National Population-Based Study of Lifelong Nonsmokers. J Obes. 2018 Nov 20; 2018:6149263. doi: 10.1155/2018/6149263.
7. Guo X, Sunil C, Qian G. Obesity and the Development of Lung Fibrosis. Front Pharmacol. 2022 Jan 10; 12:812166. doi: 10.3389/fphar.2021.8121668.
8. Hegewald MJ. Impact of obesity on pulmonary function: current understanding and knowledge gaps. Curr Opin Pulm Med. 2021 Mar 1;27(2):132–140. doi: 10.1097/MCP.0000000000000754.
9. Hornung F, Rogal J, Loskill P, Löffler B, Deinhardt-Emmer S. The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections. Int J Mol Sci. 2021 Mar 26;22(7):3456. doi: 10.3390/ijms22073456.
10. Kiley JP, Gibbons GH. Reply: Primary and Secondary Prevention of Chronic Obstructive Pulmonary Disease: Where to Next? American Journal of Respiratory and Critical Care Medicine. 2014 Oct;190(7):840–1. doi: 10.1164/rccm.201405-0883LE
11. Kisiel M, Arnfelt O, Lindberg E, Jogi O, Andrei Malinovschi, Johannessen A, et al. Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE study. 2023 Mar 1;211:107213–3. doi: 10.1016/j.rmed.2023.107213.
12. Lim Y, Boster J. Obesity and Comorbid Conditions [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. Available from: htps://www.ncbi.nlm.nih.gov/books/NBK574535
13. Sousa C, Rodrigues M, Carvalho A, Viamonte B, Cunha R, Guimarães S, et al. Diffuse smoking-related lung diseases: insights from a radiologic-pathologic correlation. Insights into Imaging. 2019 Jul 16;10(1). doi.: 10.1186/s13244-019-0765-z
14. Sutherland TJ, McLachlan CR, Sears MR, Poulton R, Hancox RJ. The relationship between body fat and respiratory function in young adults. Eur Respir J. 2016 Sep;48(3):734–47. doi: 10.1183/13993003.02216-2015.
15. Yeroshenko GА, Donets ІМ, Shevchenko KV, Ulanovska-Tsyba NA, Grygorenko AS, Sokolenko VM, et al. Restructuring of the rat pulmonary vascular bed induced by the complex of food additives. World of Medicine and Bilogy. 2023 Jan 1;19(83):197–7. doi: 10.26724/2079-8334-2023-1-83-197-202

Publication:

«World of Medicine and Biology» Vol. 19 No. 84 (2023) , с. 219-224
УДК 616.24-056.52-056.83]-018-092.9

DOI:

https://doi.org/10.26724/2079-8334-2023-2-84-219-224