GENDER DIFFERENCES IN COVID-19 VACCINATION IN UKRAINE

Authors:

Abstract:

The COVID-19 pandemic is among the greatest challenges for the worldwide. Vaccine development is an effective weapon against pandemic development. But there is a paucity of data of COVID-19 vaccine data by sex/gender in Ukraine. The purpose of the study was to assess diversity in COVID-19 vaccination among gender groups of Ukrainian population. A retrospective-archive study was conducted in Ukraine from 24 February 2021 to 16 January 2022. The obtained data showed in trends gender differences in COVID-19 vaccination status. Women preferred vaccination with Pfizer/Biontech and AstraZeneca vaccines more often than men. Significantly higher level of weekly cases among persons who received two doses than one dose of Pfizer/BioNTech vaccine with as among males (p<0.05), as females (p<0.05). These findings support idea that a gendered lens should also be applied when designing COVID-19 vaccination campaign that can help to maximize benefits and minimize adverse events.

Keywords:

vaccine SARS-CoV-2 sex Ukraine

References:

1. Allergic reactions including anaphylaxis after receipt of the first dose of Pfizer-BioNTech COVID-19 vaccine–United States, 14–23 December 2020. [(accessed on 8 November 2021)]; Available online: https://www.cdc.gov/mmwr/volumes/70/wr/mm7002e1.htm.
2. Al-Qazaz HK, Al-Obaidy LM, Attash HM. COVID-19 vaccination, do women suffer from more side effects than men? A retrospective cross-sectional study. Pharm Pract (Granada) 2022; 20(2): 2678. doi: 10.18549/PharmPract.2022.2.2678.
3. Avetikov DS., Ananieva MM, Loban GA, M.O. Faustova, M.G. Skikevych, Yu.V. Chumak et al. The profile of specific antibodies to SARS-CoV-2 in residents of the central and eastern regions of Ukraine. Sci Med Sci 2022;1(79):11–15. doi: 10.26724/2079-8334-2022-1-79-11-15.
4. Centers for Disease Control and Prevention Clinical Considerations: Myocarditis and pericarditis after receipt of mRNA COVID-19 vaccines among adolescents and young adults. [(accessed on 27 August 2021)]; Vaccines and Immunizations 2021. Available online: https://www.cdc.gov/vaccines/covid-19/clinical-considerations/myocarditis.html.
5. COVID-19 dashboard. Available online: https://moz.gov.ua/koronavirus-2019-ncov.
6. Green MS, Peer V, Magid A, Hagani N, Anis E, Nitzan D. Gender differences in adverse events following the PfizerBioNTech COVID-19 vaccine. Vaccines 2022; 10:233. doi.org/10.3390/vaccines10020233.
7. Heidari S, Palmer-Ross A, Goodman T. A systematic review of the sex and gender reporting in COVID-19 clinical trials. Vaccines (Basel). 2021;9(11):1322. doi: 10.3390/vaccines9111322.
8. Jensen A, Stromme M, Moyassari S, Chadha AS, Tartaglia MC, Szoeke C, Ferretti MT. COVID-19 vaccines: Considering sex differences in efficacy and safety. Contemp Clin Trials 2022; 115:106700. doi: 10.1016/j.cct.2022.106700.
9. Jian-Min J, Peng B, Wei H, Fei W, Xiao-Fang L, De-Min H, Shi L, Jin-Kui Y. Gender differences in patients with COVID-19: focus on severity and mortality. Front Publ Health 2020; 8:152. doi.org/10.3389/fpubh.2020.00152.
10. Kaidashev I, Shlykova O, Izmailova O, Torubara O, Yushchenko Y, Tyshkovska T, Kyslyi V, Belyaeva A, Maryniak D. Host gene variability and SARS-CoV-2 infection: A review article. Heliyon. 2021;7(8):e07863. doi: 10.1016/j.heliyon.2021.e07863.
11. Sharifi S, Caracciolo G, Pozzi D, Digiacomo L, Swann J, Daldrup-Link HE, Mahmoudi M. The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine. Adv Drug Deliv Rev 2021;174:337–347. doi: 10.1016/j.addr.2021.04.028.
12. Shevchenko MS, Mamontova TV. The role of laboratory indicators in assessing the effectiveness of vaccines against COVID-19: a systematic analysis. Problems Prospects Develop Modern Med 2021;7: 165–166. [in Russian].
13. Takahashi T, Ellingson MK, Wong P, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 2020;588(7837):315-320. doi: 10.1038/s41586-020-2700-3.
14. Trigunaite A, Dimo J, Jørgensen TN. Suppressive effects of androgens on the immune system. Cell Immunol 2015;294(2):87–94. doi: 10.1016/j.cellimm.2015.02.004.
15. Zintel S, Flock C, Arbogast AL, Forster A, von Wagner C, Sieverding M. Gender differences in the intention to get vaccinated against COVID-19: a systematic review and meta-analysis. Z Gesundh Wiss 2022;7:1–25. doi: 10.1007/s10389-021-01677-w.

Publication:

«World of Medicine and Biology» Vol. 19 No. 83 (2023) , с. 130-134
УДК 615.371:616.9

DOI:

https://doi.org/10.26724/2079-8334-2023-1-83-130-134