DISORDERS OF INNATE IMMUNITY IN VARIOUS FORMS OF THE CHRONIC ECZEMA

Authors:

Abstract:

The role of adaptive immunity in the mechanism of development of eczema as a chronic relapsing dermatosis is proven. The infectious nature of the process in microbial eczema, dysbiosis of skin microbiota and frequent bacterial complications in idiopathic (genuine) eczema primarily indicate disorders of innate immunity. The purpose of the study was to determine the cellular and humoral links of innate immunity in patients with various clinical forms of chronic eczema. Suppression of phagocytic activity of neutrophils in patients with microbial eczema due to weakening the absorbing and digesting ability (decrease in the value of the phagocytic index, phagocytic number and index of completion of phagocytosis) was established, while in patients with idiopathic eczema only the index of completion of phagocytosis was reliably reduced. For the first time, a decreased level of the antimicrobial protein lactoferrin was determined in both forms of dermatosis compared to that in individuals of the control group. The level of the antimicrobial peptide β-defensin 2 increased in all patients relative to that in the control group, more significantly in idiopathic eczema.

Keywords:

idiopathic eczema microbial eczema pathogenesis innate immunity phagocytic activity of neutrophils lactoferrin β-defensin 2

References:

1. Reztsova PA, Vashkevich AA, Raznatovskiy KI. Lecheniye mikrobnoy ekzemy s ispolzovaniyem fototerapii: sravnitelnoye issledovaniye. Lechebnoye delo. 2019; 1: 82–86. [in Russian]
2. Tlish MM, Popandopulo YeK. Etiopatogeneticheskiye aspekty razvitiya mikrobnoy ekzemy (obzor). Saratovskiy nauchno-meditsinskiy zhurnal. 2018; 14(4): 651–656. [in Russian]
3. Udzhukhu VUy, Korotkiy NG, Davtyan YeV, Kubylinskiy AA. Optimizatsiya terapevticheskikh meropriyatiy u bolnykh nummulyarnoy ekzemoy. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2017; 20(6): 364–367. [in Russian]
4. Chalaya YeL, Sorokina YeV, Akhmatova NK. Diagnosticheskoye znacheniye narusheniy v sisteme vrozhdennogo immuniteta pri mikrobnoy ekzeme. Rossiyskiy zhurnal kozhnykh i venericheskikh bolezney. 2016; 19 (2): 122–123. [in Russian]
5. Yusupova LА, Yunusova YеI, Garayeva ZSh, Mavlyutova GI, Byldyuk YeV, Shakirova AN. Sovremennyye osobennosti kliniki, diagnostiki i terapii bolnykh ekzemoy. Lechashchiy vrach. 2018: 85–87. [in Russian]
6. Hawerkamp HC, Fahy CM, Fallon PG, Schwartz C. Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis. Skin Health and Disease. 2022; 2(2): e99. doi: 10.1002/ski2.99.
7. Huls A, Abramson MJ, Sugiri D, Fuks K, Kramer U, Krutman J, Schikowski. Nonatopic eczema in elderly women: Effect of air pollution and genes. Journal of Allergy and Clinical Immunology. 2019; 143: 378–385. doi: 10.1016/j.jaci.2018.09.031.
8. Kruzel ML, Zimecki M, Actor JK. Lactoferrin in a context of inflammation-induced pathology. Frontiers Immunology. 2017; 8: 1438.doi: 10.3389/fimmu.2017.01438.
9. Le Ngoc D, Nguyen Thi VL, ThiBich NP, Chau Van T, Ngo Minh V, Nguyen Trong H, et al. In vitro antibiotic resistance in bacterial infected eczema at Ho Chi Minh City Hospital of Dermatology. Macedonian Journal of Medical Sciences. 2019;7(2): 181–183. doi: 10.3889/oamjms.2019.06.
10. Leishem Y, Hajar T, Hanifin JM, Simpson EL. What the eczema area and severity index score tells us about the severity of atopic dermatitis: an interpretability study. British Journal of Dermatology. 2015; 172(5): 1353–1357. doi: 10.1111/bjd.13662.
11. Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H. Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Experimental Dermatology. 2017: 26: 989–998. doi: 10.1111/exd.13314
12. Prasad SV, Fiedoruk K, Daniluk T, Piktel E, Bucki R. Expression and function of host defense peptides at inflammation sites. International Journal of Molecular Sciences. 2020; 21: 104.doi: 10.3390/ijms21010104.
13. Presti S, Manti S, Parisi GF, Papale M, Barbagallo IA, Li Volti G, Leonardi S. Lactoferrin: cytokine modulation and application in clinical practice. Journal of Clinical Medicine. 2021; 10: 5482.doi: 10.3390/jcm10235482.
14. Sarmiento PM, Azanza JC. Dyshidrotic eczema: A common cause of palmar dermatitis. Cureus. 2020; 12(10): e10839. doi: 10.7759/cureus.10839.
15. Yemchenko YO, Shynkevych VI, Ishcheikin KY, Kaidashev IP. PPAR-gamma agonist pioglitazone reduced CD68+ but not CD163+ macrophage dermal infiltration in obese psoriatic patients. PPAR Research. 2020;2020:4548012. doi: 10.1155/2020/4548012

Publication:

«World of Medicine and Biology» Vol. 18 No. 81 (2022) , с. 99-103
УДК 616.5-002.2:612.017.11

DOI:

https://doi.org/10.26724/2079-8334-2022-3-81-99-103