FEATURES OF LIPOPEROXIDATION AND MORPHOLOGICAL CHANGES OF THE LUNGS IN EXPERIMENTAL DIABETES MELLITUS

Authors:

Abstract:

In recent decades, diabetes has become one of the most significant medical and social problems. The prevalence and incidence of diabetes have increased dramatically in the last few years. The experiments were performed on white male rats with streptozotocin-induced diabetes. Biochemical analysis has shown that in the conditions of experimental diabetes there is an intensification of lipid peroxidation processes throughout the study period, as evidenced by a significant increase in the content of active products of thiobarbituric acid (p<0.001). The probable increase in the level of secondary products of lipid peroxidation leads to a violation of the ultrastructural organization of the components of the respiratory part of the lungs, as indicated by the results of our electron microscopic study. We found that the most expressed changes of dystrophic-destructive nature are observed in the hemocapillaries of the alveolar wall. Red blood cells sludges, adhesion, and aggregation of white blood cells and platelets are observed in the lumen of microvessels that promote the capillary-trophic insufficiency.

Keywords:

streptozotocin-induced diabetes lipid peroxidation respiratory part of the lungs

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Publication:

«World of Medicine and Biology» Vol. 18 No. 81 (2022) , с. 214-218
УДК 616.24+616.092.9+616.379-008.64

DOI:

https://doi.org/10.26724/2079-8334-2022-3-81-214-218