MORPHOLOGY AND FUNCTIONAL STATE OF THE RAT PINEAL GLAND IN CHRONIC ETHANOL INTOXICATION

Authors:

Abstract:

The purpose of the study was to establish the features of the morpho-functional state of the rat pineal gland in conditions of chronic ethanol intoxication. The results of the study showed that after 30 days of exposure to ethanol, the total number of pineal cells decreases significantly. An increase in the volume of the cytoplasm is determined due to vacuolation processes of varying degrees. Along with the decrease in the number of pinealocytes, the content of glial cells increases, which indicates a decrease in the functional activity of the pineal gland under experimental conditions. The structural organization of dark pinealocytes is also changing. Dark cell nuclei were found to lose a high degree of basophilia due to heterochromatin decondensation. Such morphological changes may indicate the transformation of dark cells in the light.

Keywords:

ethanol pineal cells gliocytes vacuolar dystrophy apoptosis rats

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Publication:

«World of Medicine and Biology» Vol. 18 No. 79 (2022) , с. 223-227
УДК 591.481.3

DOI:

https://doi.org/10.26724/2079-8334-2022-1-79-223-227