INFLAMMATION AS A RISK FACTOR OF PRETERM DELIVERY

Authors:

Abstract:

Spontaneous preterm delivery remains the leading cause of neonatal mortality and morbidity, especially in gestational periods less than 28 weeks. The content and ratio of CD-4 and CD-8 lymphocytes, as well as the concentration of interleukin-1 and interleukin-10 in the blood serum, were studied in 90 women with premature labour at 24–28 weeks and in 91 women with preterm delivery at 28–34 weeks. The control group consisted of 32 pregnant women with an uncomplicated course of pregnancy. It has been shown that in women with preterm labour at 28–34 weeks, the number of T-helpers and the concentration of pro-inflammatory cytokines was significantly higher than in healthy pregnant women. The CD-4/CD-8 index in both groups of preterm delivery was high at 1.2, while in healthy pregnant women, it was 0.8. The identified differences justify the development of treatment tactics in different gestational terms.

Keywords:

preterm delivery interleukin-1 interleukin-10 T-helpers T-suppressors

References:

1. Zahorodnia O, Leush S, Kolesnyk N. Dynamika interleikinu 8 v tservikalnomu slyzovi pry vkrai peredchasnykh polohakh – kryteriyi vyboru taktyky. Visnyk problem biolohiyi i medytsyny. 2015. 3(1): 133–136 [in Ukrainain]
2. Alijotas-Reig J, Llurba E, Gris JM. They potentiate maternal immune tolerance in pregnancy: a new challenging role for regulatory T cells. Placenta. 2014. 35(4):241–8. DOI: 10.1016/j.placenta.2014.02.004.
3. Dekel N, Gnainsky Y, Granot А, MorG. Inflammation and Implantation. American Journal of reproductive immunology. 2010. 63(1):17–21 https://doi.org/10.1111/j.1600-0897.2009.00792.
4. Dutta S, Sengupta P. Defining pregnancy phases with cytokine shift. J Pregnancy Reprod. 2017. 1: 28–32 DOI: 10.15761/JPR.1000124
5. Nadeau-Vallée M, Obari D, Quiniou C, Lubell W, Olson D, Girard S, Chemtob S. A critical role of interleukin-1 in preterm labor.Cytokine Growth Factor Rev. 2016. 28:37–51. DOI: 10.1016/j.cytogfr.2015.11.001.
6. Nakagawa K, Kwak-Kim J, Ota K, Kuroda K, Hisano M, Sugiyama R. Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood TH1/TH2 cell ratios. Am J Reprod Immunol 2015;73:353–361.
7. Orsi N, Tribe R. Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol. 2009. 20: 462–469.
8. Pei C, Kim Y, Baek K. Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects.Obstet Gynecol Sci. 2019. 62(4):212–223. DOI: 10.5468/ogs.2019.62.4.212.
9. Rajaei S, Zarnani A, Jeddi-Tehrani M, Tavakoli M, Mohammadzadeh A, Dabbagh A. Cytokine Profile in the Endometrium of Normal Fertile and Women with Repeated Implantation Failure Iran. J. Immunol. December 2011, 8 (4): 201–208.
10. Thinkhamrpop J, Hofmeyr J, Adetoro O, Lumbiganon P, Ota E. Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity. Cochrane Database Syst Rev. 2015. 26;1:CD002250. DOI: 10.1002/14651858.CD002250.pub2.
11. Shahshahan Z, Hashemi L. Maternal serum cytokines in predicting preterm labour and response to tocolytic therapy in preterm labour women.Adv Biomed Res. 2014; 3: 126. DOI: 10.4103/2277-9175.133243

Publication:

«World of Medicine and Biology» Vol. 17 No. 78 (2021) , с. 22-26
УДК 618.396-02:616-002

DOI:

https://doi.org/10.26724/2079-8334-2021-4-78-22-26