STUDY OF THE MOOMIYO-CONTAINING ORAL GEL EFFECT ON THE ACTIVITY OF THE ANTIOXIDANT DEFENSE SYSTEM IN EXPERIMENTAL PERIODONTITIS

Authors:

Abstract:

One of the important links in the study of pathogenesis indices in chronic generalized periodontitis is the intensity of lipid peroxidation and protective antioxidant systems that ensure a balance between the formation and metabolism of reactive oxygen species in cells. The purpose of our work was an experimental study of the oral cavity moomiyo-containing gel’s periodontal protection properties in the toxic calcium-deficient model. In order to simulate the pathology of periodontal disease, the laboratory white rats were given an EDTA solution (2 %) daily with drinking water, and three times a week the “Warfarin Orion” drug within 30 days. In total, 4 groups of animals were formed: group 1 – intact; group 2 – model reproduction; group 3 – model reproduction and application of “Placebo” gel to the mucous membrane of the alveolar process; group 4 – reproduction of the model and application of the moomiyo-containing gel to the mucous membrane of the alveolar process. Periodontal protective efficacy of the oral moomiyo-containing gel was shown against the background of a toxic calcium-deficient state: preservation (restoration) of protective antioxidant systems and inhibition of lipid peroxidation processes in the blood serum at the systemic level.

Keywords:

lipid peroxidation antioxidant protection experiment periodontitis oral gel

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Publication:

«World of Medicine and Biology» Vol. 17 No. 75 (2021) , с. 115-119
УДК 65.012.1[615.454.1-616.31]616-092.4:616.314.17-008.1

DOI:

https://doi.org/10.26724/2079-8334-2021-1-75-115-119