PROTEINASE-INHIBITORY POTENTIAL IN RAT PANCREAS AT THE BURN SHOCK AND TOXEMIA STAGES OF BURN DISEASE

Authors:

Abstract:

The increase in general antitryptic activity was by 1.4 times higher for 1 day (at the stage of burn shock), while the total proteolytic activity decreased, compared to the respective parameters of the pancreas in the control group of rats under the conditions of burn disease. Then both indices decrease and remain reduced for 7 days. At the next stage of toxemia (on day 7), with a burn, the total antitryptic activity in the pancreas decreases by 1.6 times compared to the control animals. On the 7-th day, the total antitryptic activity in the pancreas decreases by 2. 2 times, compared to the 1-st day. Changes in proteolytic and antitryptic activity in the rat pancreas cause changes in proteinase-inhibitory potential at the stage of burn shock and the stage of toxemia in experimental burn disease. The proteinase-inhibitory potential of the rat pancreas on the 1-st day after the burn differs from this index value on the 7-th day.

Keywords:

burn disease pancreas antitryptic activity proteolytic activity

References:

1. Hubskyi YuI. Biolohichna khimiya. Pidruchnyk. Kyiv–Vinnytsia: NOVA KNYHA; 2011. 656 s. [in Ukrainian]
2. Makarchuk VA. Osoblyvosti rozpodilu neirospetsyfichnykh bilkiv tsentralnoi ta peryferychnoi nervovoi systemy pry eksperymentalnomu khronichnomu pankreatyti. [dysertatsiya]. Dnipropetrovsk: DU “Inst. Hastroent. NAMN Ukrainy”; 2015. 168 s. [in Ukrainian]
3. Netiukhailo LH., Basarab YaO. Metabolichni zminy v nyrkakh shchuriv za riznykh stadiy opikovoyi khvoroby. Medychna ta klinichna khimiya. 2019; 21(3): 118. [in Ukrainian]
4. Syplyvyi VO, Dotsenko VV, Petrenko HD. Opikova khvoroba. Likuvannia opiku v statsionari zalezhno vid periodu opikovoyi khvoroby. Vydy khirurhichnykh operatsiy, shcho zastosovuiutsia pry likuvanni opiku: metod. vkaz. do prakt. zaniat. Kharkiv: KhNMU; 2020. 16 s. [in Ukrainian]
5. Sukhomlyn TA. Biokhimichni zminy v tkanynakh lehen za umov eksperymentalnoyi opikovoyi khvoroby ta yikh korektsiya lipinom [dysertatsiya]. Poltava: Ukr. med. stom. akad.; 2015. 145 s. [in Ukrainian]
6. Stress i proteolytycheskye fermenty lyzosom. Vestnyk VHMU. 2012;11(4) [in Russian]
7. T-kryteryi_Stiudenta. Dostupno na: https://uk.wikipedia.org/wiki/T-kryteryi_Stiudenta. [in Ukrainian]
8. Kharchenko SV. Zminy zahalnoi proteolitychnoi aktyvnosti u pidshlunkoviy zalozi na riznykh stadiyakh opikovoyi khvoroby. Visnyk problem biolohiyi i medytsyny. 2018;2(144):245–7. [in Ukrainian]

Publication:

«World of Medicine and Biology» Vol. 16 No. 74 (2020) , с. 188-192
УДК [616.37 + 616 - 001.17]:559.323.4

DOI:

https://doi.org/10.26724/2079-8334-2020-4-74-188-192