GLUCOCORTICOIDS AS IMMUNOSTIMULATORS IN PATHOGENETIC THERAPY OF TUBERCULOSIS

Authors:

Abstract:

The immunostimulating effect of corticosteroids in the complex treatment of tuberculosis patients when they are administered in a double physiological dose, every other day, taking into account the circadian rhythm of the function of the hypothalamic-pituitary-adrenal axis was substantiated in the article. Whereas with daily administration, corticosteroids have shown an immunosuppressive effect. Peripheral blood B-lymphocytes are not sensitive to glucocorticosteroid drugs.

Keywords:

tuberculosis pathogenetic therapy glucocorticosteroids

References:

1. Barkanova ON, Gagarina SG, Kaluzhenina AA. Steroidnyi tuberkulez. Medical sciences/Colloquium-journal. 2020; 5(57):30-2. [in Russian]
2. German A.O. Pokazateli tsitokinovoy aktivnosti pri vpervye diagnostirovannom tuberkuleze legkikh s razlichnoy chuvstvitelnostyu k khimiopreparatam v zavisimosti ot pokazateley tireoidnogo gomeostaza i soderzhaniya kortizola. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2015; 1:79-82. [in Russian]
3. Kuzhko MM, Prosvyetov YuV, Gulchuk NM, Avramchuk OV, Gusarova AYu. Efektivnist likuvannya ta profilaktika alergichnykh uskladnen u khvorykh na tuberkuloz lehen. Astma ta alerhiya. 2014; 1:30-4. [in Ukrainian]
4. Kuznetsova LV, Frolova VM, Babadzhan VD, redaktori. Klinichna ta laboratorna imunolohiya. Natsionalnyi pidruchnyk. Kyiv: OOO “Poligraf plus”; 2012. 922 s. [in Ukrainian]
5. Kulish MV. Glyukokortikoyidy yak zasib patohenetychnoyi terapiyi tuberkulozu. Svit medytsyny ta biolohiyi. 2013; 40(3):88-91. [in Ukrainian]
6. Litvinenko AV. Obshchie printsipy sistemnoy glyukokortikosteroidnoy terapii. Ukrayinskiy pulmonologichnyi zhurnal. 2014; 1:60-4. [in Russian]
7. Maksimov GV, Mukomolov SL, Ivanov AK. Bezopasnost terapii prednizolonom v lechenii bolnykh tuberkulezom i VICh-infektsiey. Infektsiya i immunitet. 2013; 3(4):341–6. [in Russian]
8. Mordyk AV, Batisheva TL, Bryuhanova NS, Puzyreva L.V. Vliyanie immunologicheskih narusheniy na khod vpervye vyyavlennogo infiltrativnogo tuberkuleza u sotsialno sohranennykh patsientov. Infektsiya i immunitet. 2014; 4(4):353-8. [in Russian]
9. Poletaeva AV, Levanyuk AI, Sergeeva EV. Vliyanie gormonov na immunologicheskuyu reaktivnost. Obzor. Ekologiya cheloveka. 2009; 7:42-6. [in Russian]
10. Protsyuk RG, Zaguta YuB. Funkcionalniy stan adrenokortikalnoyi sistemy u hvorykh z ko-infektsiyeyu tuberkulozu VIL. Tuberkuloz, lehenevi khvoroby, VIL-infekciya. 2015; 4(23):12-5. [in Ukrainian]

Publication:

«World of Medicine and Biology» Vol. 16 No. 73 (2020) , с. 144-148
УДК 616.24-002.5:615.37

DOI:

https://doi.org/10.26724/2079-8334-2020-3-73-144-148