ASSESSMENT OF IMMUNOLOGICAL DISORDERS IN THE GENESIS OF BRONCHIAL ASTHMA IN CHILDREN WITH DIFFERENT DEGREES OF THE DISEASE CONTROLLABILITY

Authors:

Abstract:

It is established that children with bronchial asthma may have pronounced changes in their immunological status, concerning both its cell and humoral components, and to a significant extent they are determined by the disease severity. In the examined patients with bronchial asthma, a limited reserve of phagocytic cells and their phagocytic activity have been established. The maximum inhibition of phagocytosis was observed in patients with uncontrolled bronchial asthma (p <0.05). At the same time, in patients with uncontrolled and partially controlled bronchial asthma, a reduction of their regulatory index was registered, which was caused by the reduction of CD4+ portion and the increase of CD8+ content (p <0.05). Manifestation of a positive highest degree correlation (r=0.79, p<0.05) between the blood serum IL-6 content and the BA course severity in children.

Keywords:

bronchial asthma children immunity

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Publication:

«World of Medicine and Biology» Vol. 16 No. 71 (2020) , с. 78-83
УДК 613.955+616-08

DOI:

https://doi.org/10.26724/2079-8334-2020-1-71-78-83