STUDYING THE PROPERTIES OF HORMONALLY ACTIVE FORMS OF CHOLECALCIFEROL WITH VIKASOLUM DURING EXPERIMENTAL PERIODONTITIS IN RATS

Authors:

Abstract:

The total of 25 white rats males 1.5-2 - months of age were included in the experiment. Intact group comprised 7 specimens. In the control group, a model of periodontitis was reproduced (7) with administering pelentan per os and replacement of drinking water with 2% EDTA ad libitum. The hormonal forms of vitamin D3 were administered per os in doses per rat a day: 0.1 μg 1.25(OH)2D3 (5 animals) and 1.25 μg 24.25(OH)2D3 (6 animals) together with Vicasolum at a dose of 1.5 mg for 60 days. The hormonal forms of vitamin D3 with Vicasolum showed anti-osteo-resorptive, periodontal protective properties, which resulted in a decrease in the level of periodontal bone resorption, LPO products; activation of antioxidant enzymes; increasing the level of sulfhydryl groups of proteins in the mucous membrane of the oral cavity and the alveolar bone.

Keywords:

hormonal forms of cholecalciferol vitamin K lipid peroxidation periodontal protective properties antioxidant enzymes sulfhydryl groups of proteins rats

References:

1. Bogacheva YeV, Alabovskiy VV, Perov SYu. Opredeleniye kontsentratsii malonovogo dialdegida v syvorotke krys, obluchennykh elektromagnitnym polem metrovogo diapazona. Izvestiya Saratovskogo universiteta. Novaya seriya. Seriya Khimiya. Biologiya. Ekologiya. 2016; 16(1): 70-74. [in Russian]
2. Kosenko KN, Tkachenko YeK, Novoselskaya NG. Korrektsiya metabolicheskikh narusheniy soyedinitelnotkannogo matriksa parodonta krys polifenolami rastitelnogo proiskhozhdeniya v usloviyakh modelirovaniya parodontita. Tavricheskiy mediko-biologicheskiy vestnik. 2012. [in Russian]
3. Kostyuchenko LA, KharitonovaNS, Vdovin VM. Effektivnost ispolzovaniya sochetannogo vitaminnogo kompleksa: vitamin d i vitamin K. Byulleten meditsinskoy nauki. 2018; 3 (11): 33-40. [in Russian]
4. Maltsev SV, Mansurova GSh. Metabolizm vitamina d i puti realizatsii yego osnovnykh funktsiy. Prakticheskaya meditsina. 2014; 9(85): 12-18. [in Russian]
5. Nikolayeva AV. Izucheniye vliyaniya kompleksa rastitelnykh polifenolov, vitamina k i mineralov na sostoyaniye tkaney parodonta krys v usloviyakh modelirovaniya parodontita. Ukrayinskyi stomatolohichnyi almanakh. 2016; 2: 13-17. [in Russian]
6. Oynotkinova OSh, Dedov YeI. Dislipidemiya i assotsiirovannyye metabolicheskiye zabolevaniya. Arkhiv vnutrenney meditsiny. 2011; 1: 67-73. [in Russian]
7. Petrovich YuA. Prooksidanty, meksidol i drugiye antioksidanty pri gerpeticheskom stomatite, gingivostomatite i khronicheskom generalizovannom parodontite. Rossiyskiy stomatologicheskiy zhurnal. 2010; 3: 29-33. [in Russian]
8. Popov KA, Melkonyan KI, Kartashevskaya MI. Konformatsionnyye izmeneniya belkov plazmy krovi pri sochetannom techenii sakharnogo diabeta 2 tipa i psoriaza. Sovremennyye problemy nauki i obrazovaniya. 2015; 1: 1. [in Russian]
9. Spirichev VB, Gromova OA. Vitamin d i yego sinergisty. Zemskiy vrach. 2012; 2: 33-38.
10. Unguryanu TN, Grzhibovskiy AM. Kratkiye rekomendatsii po opisaniyu, statisticheskomu analizu i predstavleniyu dannykh v nauchnykh publikatsiyakh. Ekologiya cheloveka. 2011; 5. [in Russian]
11. El Ta’alu Abbas, Kot YuG, Perskiy YeE, Ponomarenko AN. Svyaz mezhdu vozrastnymi izmeneniyami belkovo-polisakharidnogo sostava i biomekhanicheskimi svoystvami kozhi. Visnyk Kharkivskoho natsionalnoho universitetu im. V.N. Karazina. Ser.: Biolohiya. 2010; 905(11): 37 – 42. [in Russian]
12. Schnaider SA, Anisimov MV, Maslov AV, Tkachenko EK. Study of the influence of the vitamin-mineral complex "Silicon active" on the condition of the periodontal tissues of rats during the modeling of periodontitis. Journal of Education, Health and Sport. 2017; 7(7): 1229-1237.

Publication:

«World of Medicine and Biology» Vol. 15 No. 69 (2019) , с. 234-238
УДК (615.356.577.16)-092.19:616.314.17-008.1:599.238

DOI:

https://doi.org/10.26724/2079-8334-2019-3-69-234-238