IMPACT OF MULTIPROBIOTICS ON THE CONTENT OF TBA-REACTIVE SUBSTANCES IN THE BLOOD SERUM AND MUCOUS MEMBRANES OF THE STOMACH AND COLON IN RATS WITH LONG-TERM GASTRIC HYPOCHLORHYDRIA

Authors:

Abstract:

It has been established that after 28 days of administering omeprazole to rats, the TBARS content had grown in all the studied media: in the blood serum, by 92.1% (p <0.001); in the gastric mucosa, by 352.4% (p < 0.001) and in the mucous membrane of the colon, by 57.3% (p <0.01) compared to that of the control group. Under the conditions of the concomitant 28-day administration of omeprazole and Simbiter multiprobiotic, the TBARS content in the blood serum was the same as that in the control group rats. After 28 days of co-administering omeprazole and the “Apibact” multiprobiotic, the TBARS content in the blood serum was even by 41.4% (p <0.05) lower than that in the control group. After 28 days of co-administering of omeprazole and Simbiter multiprobiotic, the TBARS content in the rat gastric mucosa was by 64.4% (p <0.01) lower than in the group of rats given omeprazole only. In the concomitant administration of the “Apibact” multiprobiotic with omeprazole, the TBARS content in the gastric mucosa was by 57.8% (p <0.01) smaller in comparison with the same value in the group of rats, which was administered omeprazole only for 28 days. "Simbiter" and "Apibact" multiprobiotics in the conditions of the 28-day concomitant administration with omeprazole reduced the TBARS content in the colon mucous membrane by 18.4% (p <0.05) and 39.0% (p <0, 05), respectively.

Keywords:

hypochlorhydria probiotics TBA-reactivesubstances (TBARS) mucous membrane of the stomach mucous membrane of the colon

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Publication:

«World of Medicine and Biology» Vol. 14 No. 65 (2018) , с. 218-222
УДК 615.24:591.41/.434]:599.323.4

DOI:

https://doi.org/10.26724/2079-8334-2018-3-65-218-222