ULTRASTRUCTURE OF THE PLACENTA DURING PARVOVIRUS INFECTION B19

Authors:

Abstract:

Response in Placental Tissues – cytotrophoblast and plasmodiotrophoblast to parvovirus B19 and its cytotoxic influence on cells cause pathogenic abnormality, such as aborts and fetal death in terms of 21 weeks’ gestation. To cytopathic effect of virus include formation in the nucleus of endothelial cells of blood capillary as well as myelin figures in cytoplasm, which are connected with enchancement of lipid peroxidation. The method of electron microscopy provides additional information about the cause of immature birth and embryofoetal death with non-immune hydrop in the second trimester of pregnancy with ELISA doubtful results on parvovirus infection B19. Parvovirus B19 viral particles imaging in 100% cases of termination with edema syndrome in the fetus and placenta in terms of the 15-19 weeks, at the same time as mothers infected by acute parvovirus infection (detection of human parvovirus B19-specific IgM and IgG antibodies) only in 62,5% cases was diagnosed by ELISA.

Keywords:

Human parvovirus (hPV) B19 infection parvovirus B19 virions non-immune hydrops embryofoetal death immature birth cytotrophoblast plasmodiotrophoblast pregnancy

References:

1. Bondarenko N.P. Diagnostichna tsinnist kombinovanogo metodu imunofermentnogo analizu ta polimeraznoyi lantsyugovoyi reaktsiyi dlya viyavlennya vnutrishnoutrobnogo infikuvannya ploda / N.P. Bondarenko, V.P. Lakatosh, P.V. Lakatosh [ta in.] // Likarska sprava .-2015.- No.3-4-S. 121-128
2. Anne M. Detection of D19 Parvovirus in Human Fetal Tissues by Electron Microscopy / M. Anne, K.E. Field, B.J. Cohen [et al.] // Journal of Medical Virology.-1991.-№35-P. 85-95.
3. Brown T. Intrauterine parvovirus infection associated with hydrops fetalis / T. Brown, A. Anand, L.D. Richie [et al.] //-Lancet: P. 1033-1034.- 1984.
4. Butchko A.B. Comparison of three commercially available serologia assays used to detect human parvovirus B19-soecific immunoglobulin M(IgM) and IgG antibodies in sera of pregnant woman / A. B. Butchko, I. A. Jordan // Clin Microbiol.-2004.- №42(7).-Р.3191-3195.
5. Burton T. Intranuclear inclusions in marrow of hydrops fetus due to parvovirus infection/ T. Burton, D. Carrington, D. Gilmone [et al.] // Lancet ii – P. 1115.-1986.
6. Caul E.O. Intrauterine infection with human parvovirus B19: a light and electron microscopy study / E. O. Caul, M. J. Usher, P. A. Burton // Journal of Medical Virology.- 1988. - №24- P.55-66.
7. Jordan J. A. Infect Dis Obstet Gynecol / J.A. Jordan //-2004.- №12 (2).-Р.69-78.
8. Young N.S. Mechanisms of disease: Parvovirus B19 / Young N.S. Brown K.E. // Eng. J. Med- 2004.-№350- Р.586-598.

Publication:

«World of Medicine and Biology» Vol. 12 No. 56 (2016) , с. 106-110
УДК 618.36-07:616.916.1