THE INFLUENCE OF TOXIC DOSES OF OLIGOESTERS ON CARBOHYDRATE AND ENERGY METABOLISM OF LIVER OF WHITE RATS IN EXPERIMENT

Authors:

Abstract:

The aim was to study the effect of long-term subtoxic influence of oligoesters on two brands of carbohydrate and energy metabolism of the liver in a subacute toxicological experiment on white rats. Xenobiotics L -3603-2-12 and L -10002-2-80 at a dose 110 і 1100 DL50 violate carbohydrate metabolism in the background of oppression bioenergetic processes. at a dose 1100 DL50 oligoesters stimulate the recovery of synthesis, which can be considered as voltage protective and adaptive mechanisms to ensure homeostatic functions. Oligoesters at long toxification 110 DL50 lead to the disruption of protective-adaptive mechanisms and the development of hypotoxical states that underlies the formation of dystrophic and destructive processes, the leading element of which is a membrane pathology.

Keywords:

oligoesters metabolism toxicity health

References:

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Publication:

«World of Medicine and Biology» Vol. 12 No. 55 (2016) , с. 178-182
УДК 613.2 - 613.29 - 615.244 - 615.245 - 615.246