ROLE OF INSULIN-LIKE GROWTH FACTOR-1 IN PATHOGENESIS OF CHRONIC ALCOHOLIC LIVER DISEASE IN RATS OF DIFFERENT AGE GROUPS

Authors:

Abstract:

During last ten years, chronic diffuse liver disease due to high morbidity and life-threatening consequences related to the actual problems of modern medicine. The actual topic is to study molecular mechanisms of reparative regeneration of pathological-altered liver and drugs influence on this process. The perspective is the studying of insulin-growth factor-1 (IGF-1) in rats of different age groups with chronic alcohol liver disease and under condition of pharmacocorrection using L-arginine-L-glutamate and quercetin, and study the correlation between IGF-1 and changes of biochemical markers of blood serum. Has been proved that chronic alcohol liver disease decreases the concentration of IGF-1 in the animals of all age groups, which correlates with biochemical markers of cytolysis and cholestasis syndromes. Established that under condition of pharmacocorrection using L-arginine-L-glutamate significantly increases the level of IGF-1, and available direct significant correlation with parameters of functional liver state, indicating restoration of liver parenchyma and its functional state by activation of reparative regeneration. Gained data shows that hepatoprotector L-arginine-L-glutamate has a potitive influence on the regenerative reparation process compared with quercetin.

Keywords:

age features chronic alcohol liver disease insulin-like growth factor-1 biochemical parameters

References:

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Publication:

«World of Medicine and Biology» Vol. 11 No. 53 (2015) , с. 129-135
УДК 577.17:591.436:599.323.4