THE STATE OF IMMUNOBIOLOGICAL REACTIVITY IN ANIMALS IN RESPONSE TO PROLONGED SUBTOXIC EXPOSURE TO LAPROXIDES

Authors:

Abstract:

The research deals with the study of the effect exerted by subtoxic doses of laproxides L-303 and L-500 on allergenic properties as well as on the state of cellular and humoral immunity in experimental animals. Laproxide L-303 testing determined clinical and skin manifestations of sensibilization in animals and their absence when testing L-500. In the dosage of 1/100 and 1/1000 LD50 L-303 inhibits cellular and humoral immunity, DNA, RNA and protein synthesis, induces pro-inflammatory reactions. Laproxide L-500 in the dosage of 1/100 LD50 inhibits cellular and humoral immunity, suppresses DNA, RNA and protein synthesis with underlying activation of pro-tumor cytokines. L-500 in the dosage of 1/100 LD50, L-303 in the dosage of 1/100 and 1/1000 LD50 have been found to condition the development of immunological deficiency and the dysfunction of immunological reactivity.

Keywords:

xenobiotics laproxides sensibilization immunological deficiency

References:

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Publication:

«World of Medicine and Biology» Vol. 10 No. 47 (2014) , с. 206-210
УДК 612.017.1:616-099-092.9:547.911-311-145.82