MORPHOLOGICAL CHANGES OF THE BRAIN CORTEX OF RATS WITH PRIMARY AND REPEATED STROKE

Authors:

Abstract:

The dynamics of morphological changes in rat brain in experimental primary and secondary hemorrhagic stroke was establish. Repeated simulated stroke 1 month after the initial stroke. Histological evaluation was performed on the 3th, 21th day, after 3 and 6 months after stroke in a test area the size of 1-2 mm. Degenerative dameged modified neurons with signs of cytolysis, kariolisis with homogeneously colors acidophilic nuclei or with signs piknozis. Are studied structurally-morphological changes at primary and repeated hemorrhagic stroke. The pathogenesis of primary and repeated hemorrhagic stroke is characterized by progressive dynamics of brain tissue edema and degenerative changes. When repeated stroke reliable growth changes in the cerebral cortex exacerbates neurological deficit, is an unfavorable factor recovery period and requires further study of the pathophysiological level.

Keywords:

primary hemorrhagic stroke repeated stroke neurodegeneration brain cortex

References:

1. Виберс Д. Инсульт (клинич. рук.) / Д. Виберс, В. Фейгин, Р. Браун // - М. : БИНОМ, - 2005. - 608 с.
2. Макаренко А.Н. Метод моделирования локального кровоизлияния в различных структурах головного мозга у экспериментальных животных / А.Н. Макаренко, Н.С. Косицын, Н.В. Пасекова [и др.] // Журн. высш. нервн. деятельн. – 2002. – Т. 52, № 6. – С. 765-768.
3. Никифоров Б.М. Лечение больных среднего и пожилого возраста с гипертоническими гематомами супратенториальной локализации / Б.М. Никифоров, Ж. Закарявичус // Матер. III съезда нейрохирургов России. - 2002. - С. 345-346.
4. Скворцова В.И. Геморрагический инсульт / В.И. Скворцова, В.В. Крылов // - М : ГЭОТАР-Медиа, - 2005. - 160 с.
5. Christoforidis G. Hemorrhage volume as an objective measure to define significant intracranial hemorrhage associated with thrombolysis / G. Christoforidis, A. Slivka Y. Mohammad [et al.] // Stroke. – 2007. – Vol. 38, № 7. – Р. 1799-1804.
6. Lansberg M. Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke / M. Lansberg, V. Thijs, R. Bammer [et al.] // Stroke. – 2007. – Vol. 38, № 8. – P. 2275-2278.
7. Paxinos G. The rat brain in stereotaxic coodiates / G. Paxinos, C. Watson. - San Diego // -: Academic Press, - 2008. – 400 p.
8. Pierot L. Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management / L. Pierot, M. Aggour, J. Moret // - 2010. – Vol. 16. – P. 110-116.

Publication:

«World of Medicine and Biology» Vol. 9 No. 42 (2013) , с. 81-84
УДК 616.831-005.1-005.4-036