VENOUS HYPOXEMIA AND CAPILLARY LEAK SYNDROME WITH THE PATIENTS WITH ABDOMINAL SEPSIS AT A HIGH MORTALITY RISK

Authors:

Abstract:

64 patients with abdominal sepsis who had high initial estimation points according to the Acute Physiology And Chronic Health Evaluation-II were examined for the mixed venous blood saturation with oxygen and for the volumes of body fluid areas during the week after the operation. Venous hypoxemia has been shown to associate with an excessive fluid accumulation in the interiticium. The severity degree of venous hypoxemia was fully correspondent to the severity of edema syndrome. The correlation analysis has shown a strong feedback between the venous blood saturation with oxygen and the severity of capillary leak syndrome development. Performing a liquid resuscitation with different groups of up-to-date plasma substitutes revealed that the best effect for the capillary leak limitation was shown by hydroxyethylstarch derivatives.

Keywords:

abdominal sepsis venous blood saturation with oxygen capillary leak syndrome plasma substitutes crystalloids gelatine hydroxyethylstarch correlation analysis

References:

1. Беляев А.В. Синдром капиллярной утечки /А.В.Беляев // Мистецтво лікування. – 2005. – №24. – С.92 – 101.
2. Жалко-Титаренко В.Ф. Водно-электролитный обмен и кислотно-основное состояние в норме и при патологии / В.Ф.Жалко-Титаренко – Киев: Здоров’я, 1989. –200с.
3. Курсов С.В. Спосіб визначення об’єму циркулюючої крові / С.В.Курсов // Реєстр галузевих нововведень. – 2009. –№30 -31. – С. 28.
4. Мальцева Л.А. Сепсис: этиология, эпидемиология, патогенез, диагностика, интенсивная терапия / Мальцева Л.А., Усенко Л.В., Мосенцев И.Ф. – Москва: МЕДпресс-информ, 2005. – 176с.
5. Мартиросов Э.Г. Технологии и методы определения состава тела человека. / Мартиросов Э.Г., Николаев Д.В., Руднев С.Г. – Москва: Наука, 2006. – 248с.
6. Минцер О.П. Методы обработки медицинской информации / Минцер О.П., Угаров Б.Н., Власов В.В. – Киев: Вища школа, 1991. – 271с.
7. Рябов Г.А. (1988) Гипоксия критических состояний / Г.А.Рябов – Москва: Медицина, 1988 – 288с.
8. Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock / G.Marx, S.Pedder, L.Smith [et al.] // Critical Care Medicine. – 2006. – Vol.34, №12. – Р.3005 – 3010.
9. Fishel R.S. Vessel injury and capillary leak / R.S.Fishel, Ch.Are, A.Barbul // Critical Care Medicine. – 2003. – Vol.31, №8. – Р.502 – 511.
10. Is there a difference in mortality between patients admitted to ICU/HDU with acute hypoxaemic respiratory failure from pulmonary and extra-pulmonary causes: A study of 57706 patients / G.Bellingan, H.Wunsch, D.Young [et al.] // American Journal of Respiratory and Critical Care Medicine. – 2004. – Vol. 169. – A17.
11. Johan Groeneveld A.B. Extravascular lung water to blood volume ratios as measures of permeability in sepsis-induced ALI / ARDS / A.B.Johan Groenveld // Intensive Care Medicine. – 2006. – Vol. 32, №9. – Р.1315 – 1321.
12. Marx G. Fluid Management in Sepsis: Colloids or Crystalloids? / G.Marx, T.Schuerholz, K.Reinhart // Intensive Care Medicine. – 2007. – Vol.33, №11. – Р.563 –573.
13. Mehta D.Signaling mechanisms regulating endothelial permeability / D.Mehta, A.B.Malik // Physiological Reviews. – 2006. – Vol.86. – P.279 – 367.
14. Prognostic value of extravascular water in critically ill patients / S.G.Sakka, M.Klein, K.Reinhart [et al.] // Chest. – 2002. – Vol.122, №6. – Р.2080 – 2086.
15. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 / R.P.Dellinger, M.M.Levy, J.M.Carlet [et al.] // Intensive Care Medicine. – 2008. – Vol. 34. – P.17–60.

Publication:

«World of Medicine and Biology» Vol. 8 No. 34 (2012) , с. 98-101
УДК 616.94:616