ALANINE AMINOTRANSFERASE ACTIVITY IN RATS OF DIFFERENT AND IN CONDITIONS OF PERIODICAL INJECTION OF MULTIPROBIOTIC «SYMBITER® ACIDOPHILIC»
Experemental medicine

ALANINE AMINOTRANSFERASE ACTIVITY IN RATS OF DIFFERENT AND IN CONDITIONS OF PERIODICAL INJECTION OF MULTIPROBIOTIC «SYMBITER® ACIDOPHILIC»

Published 2012-05-22

Authors:

L.О. Torgalo
О.V. Таburets
T.V. Beregova
L.I. Ostapchenko
D.S. Yankovsky

Abstract:
It was established, that activity of alanine aminotransferase in serum is decreasing in rats with age (from 3 to 18 months). Periodical administration (every 3 months during 10 days) to the rats multiprobiotic "Symbiter® acidophilic" prevents the age-related changes in the enzyme activity. Thus activity of alaninaminotranspherase may be serve as biomarker of aging and periodical use of multiprobiotic may to some extent prevent age-related changes in activity of alanine aminotransferase.
Keywords:
ontogenesis alanine aminotransferase multiprobiotic
References:
  1. Торгало Є.О. Вплив мультипробіотика «Симбітер® ацидофільний» на вміст продуктів перекисного окиснення ліпідів у сироватці крові та тканинах внутрішніх органів у щурів різного віку / Є.О.Торгало, Т.В. Довбинчук, Л.І. Остапченко // Вісник Київського національного університету імені Тараса Шевченка. Серія Проблеми регуляції фізіологічних функцій. – 2011. - № 14. – С. 46-47.
  2. A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen. Taiwan / C-M. Liu, T-H Tung [ et al]. // World J Gastroenterol. – 2005. – Vol. 11. – P. 1616-1622.
  3. Dong M.H. Alanine Aminotransferase decreases with Age: The Rancho Bernardo Study / M.H Dong, R. Bettencourtz, E. Barrett-Connorz // Plos ONE. - plosone.www.org. – 2010. – V. 5, Issue 12. – e14254.
  4. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern / E. Elinav, I.Z. Ben-Dov [et al.] // Am J Gastroenterol. – 2005. – Vol. 100. – P. 2201-2204.
  5. Hall K.E. American Gastroenterology Association Future trends Committee Report: Effects of aging of the population on gastroenterology practice, education and research / K.E.Hall, D.D.Proctor, L.Fisher // Gastroenterology. – 2005. – Vol. 129. – P. 1305-1308.
  6. Ioannou G.N. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1992-2002 / G.N. Ioannou, E.J Boyako, S.P. Lee // Am J Gastroenterol. – 2006. – Vol. 101. – P. 66.-72.
  7. Khedmat H. Serum g-glutamiltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men / H. Khedmat, F. Fallahian., В. Hajibeigi // World J Gastroenterol. – 2007. – Vol. 13. – P. 889-894.
  8. Leclercq I. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors/ I. Leclercq, Y. Horsmans, М. De Bruyere // Acta Gastroenterol Belg. – 1999. – Vol. 62. – P. 16-20.
  9. Le Couteur D.G.The association of alanine transaminasewith aging, frailty, and mortality/ D.G. Le Couteur, F.M. Blyth, H.M. Creasey // J Gerontol A Biol Sci Med Sci. – 2010. – Vol. 65. – P. 712-717.
  10. Liangpunsakul S. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: Results from the third national health and nutrition survey (NHANES III) / S. Liangpunsakul, N. Chalasani // Am J Med Sci. – 2005. – Vol. 329. – P. 111-116.
  11. Mohamadnejad M. Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors / М. Mohamadnejad, А. Pourshams, R. Malekzadeh. // World J Gastroenterol. – 2003. – Vol. 9. – P. 2322-2324.
  12. Patt C.H. Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program/ С.Н. Patt, H.Y Yoo, К. Dibadj // Dig Dis Sci – 2003. – Vol. 48. – P. 797-801.
  13. Reevaluation of serum alanine aminotransferase upper limit and its modulation factors in a large-scale population study / R. Kariv, М. Leshno [et al.] // Liver International. – 2006. – Vol. 26. – P. 445-450.
  14. Reitman S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvatic transaminases / S. Reitman, S. Frankel // Am. J. Clin. Pathol. – 1957. – V. 28, N 1. – P. 56-63.
  15. Ruhl C.E. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States Ruhl C.E. Ruhl, J.E. Everhart // Gastroenterology. – 2003. – Vol. 124. – P. 71-79.
Publication:
«World of Medicine and Biology» Vol. 8 No. 33 (2012) , с. 163-166
УДК 612.66:612