THE INFLUENCE OF PALEOCEREBELLAR CORTEX ASPIRATION UPON FORMATION OF EPILEPTIC FOCI IN BRAIN CORTEX OF RATS WITH RESISTANT FORM OF EPILEPTIC SYNDROME

Authors:

Abstract:

In acute experiments on male Wistar rats on the model of resistant form of epileptic syndrome, which was induced in the course of three weeks corazol administration (30,0 mg/kg, i.p.) fiollowed by four weeks free from epileptogen administrations, it was established that paleocerebellar cortex aspiration shortened the time of epileptic discharges appearance, which were induced in frontal cortex by applications of penicillin sodium salt solution (10.000 IU/ml). Besides, the shortening of the time of gaining maximal magnitude of discharges was established along with increasing their amplitude and shifting of the mode of interspike intervals to the side of their shortening. The aspiration of paleocerebellar cortex increased the time of existence of epileptic foci.

Keywords:

epileptic focus paleocerebellar cortex penicillin resistant form of peileptic syndrome

References:

1. Годлевский Л.С., Коболев Е.В., Смирнов И.В. Стимуляция мозга: механизмы прекращения судорожной активности.- Одесса: Н.Технология.- 2006.- 183 с.
2. Моделирование и механизмы подавления экспериментального эпилептического синдрома / Л.С.Годлевский, Е.В.Коболев, В.Ф.Мустяца, Г.А.Дроздова // Одесса: КП ОГТ.- 2010.- 350 с.
3. Жилінська Г.В. Вплив аспірації палеоцеребелярної кори на формування каїнат- провокованих вогнищ епілептогенезу в корі головного мозку щурів// Буковинський медичний вісник.- 2001.- №1.- С.159-162.
4. Шандра А.А., Годлевский Л.С., Брусенцов А.И. Киндлинг и эпилептическая активность. Одесса, Астропринт.-1999.- 270 с.
5. Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center/ M.V.Recio, M.J.Gallagher, M.J.McLean, B.Abou-Khalil // Epilepsy Research.- 2007.- Vol.76,N1.-P.1-5.
6. S.Pati, A.V.Alexopoulos Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies / S.Pati, A.V.Alexopoulos // Cleveland Clinic Journal of Medicine.- 2010.- Vol. 77, N 7.- P. 457-467.

Publication:

«World of Medicine and Biology» Vol. 7 No. 30 (2011) , с. 21-24
УДК 616.831.31-009.24- 092.9