SWIMMING BEHAVIOR AND AGGRESSIVENESS OF KINDLED RATS UNDER CONDITIONS OF NITROGEN OXIDE PRODUCTION MODULATION

Authors:

Abstract:

Reduced variablity of kindled rats swimming was reversed by L- arginine (500 mg/kg, i.p.) by 19,0% pertained to that one detected in kindled not- treated animals (control). L- arginine and L-NAME did not influence the variability of intact rats swimming. The increased threshold of kindled rats escape from water pool was reversed by L- arginine (200,0 and 500,0 mg/kg) by 65,3% and 119,7% correspondently. L-NAME (10,0 mg/kg) caused the threshold elevation by 71,2%. L- arginine induced the elevation while L-NAME decreased the threshold of intact rats escape – correspondently by 22,4 and 37,5% when used in maximal dosages. Kindling- induced reduction of the aggressive reactions threshold was reversed by L-arginine (500,0 mg/kg) by 29,0%. L-NAME (10,0 mg/kg) suppressed the threshold of animal fights by 23,3%. L- arginine (500,0 mg/kg) when used in intact rats caused the elevation of the aggressive reactions threshold by 24,8%.

Keywords:

kindling epileptic activity swimming behavior aggressiveness nitrogen oxide

References:

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Publication:

«World of Medicine and Biology» Vol. 7 No. 28 (2011) , с. 14-18
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