CLINICAL AND LABORATORY OUTCOMES OF COMPLEX THERAPY IN PATIENTS WITH CHRONIC SIALADENITIS IN THE EXACERBATION STAGE

Authors:

Abstract:

Chronic sialadenitis is one of the most common recurrent salivary gland diseases, complicating treatment in maxillofacial practice due to its long course and frequent exacerbations. The purpose of the study was to evaluate the clinical and laboratory effectiveness of complex therapy combining conventional treatment with local immunotherapy using autologous leukocytes stimulated by a synthetic immunomodulatory peptide. Forty-five patients were examined: the control group received standard therapy, while the main group additionally underwent three intraductal administrations of stimulated leukocytes. Complex treatment led to faster symptom regression, improved salivary parameters, normalization of the cytokine profile, and a lower recurrence rate (12 % vs. 35 %). The findings suggest that the combined therapeutic approach improves both short-term clinical recovery and long-term disease control.

Keywords:

chronic sialadenitis salivary glands immunotherapy cytokines sialometry

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 12-16
УДК 616.316.2-002.2-085

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-12-16