COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF NOVEL PROGNOSTIC MARKERS OF POSTPARTUM INFLAMMATORY COMPLICATIONS

Authors:

Abstract:

Postpartum inflammatory complications remain a significant medical and social problem and significantly affect maternal morbidity rates. The purpose of this study was to evaluate the effectiveness of Raman spectroscopy as a prognostic marker for inflammatory complications in the postpartum period, compared with traditional laboratory parameters. The study included 300 women in labor (250 women with inflammatory complications and 50 women in the control group). A reliable gradation dependence of the frequency and intensity of spectral peaks on the clinical severity of the inflammatory process has been established. High values of spectral parameters correlated with an increase in C-reactive protein, procalcitonin, IL-6, fibrinogen, neutrophil-lymphocyte ratio, and erythrocyte sedimentation rate (p<0.001). The analysis of clinical, laboratory, and spectroscopic data indicates the high diagnostic and prognostic significance of Raman spectroscopy in assessing inflammatory complications of the postpartum period. It was found that changes in the intensity of characteristic spectral bands (Amide I, Amide III, phenylalanine ~1003 cm⁻1, lipid bands 1445 and 2850-2930 cm⁻1) correlate with increased levels of CRP, procalcitonin, IL-6, fibrinogen, as well as with an increase in the NLR index and ESR. The sequential increase in protein and lipid peaks, accompanied by an increase in the frequency of complications, reflects activation of the cytokine cascade, synthesis of acute-phase proteins, and the development of oxidative stress. This confirms Raman spectroscopy's ability to detect molecular changes preceding the clinical manifestation of severe inflammation. Thus, Raman spectroscopy can be considered an effective additional prognostic marker of systemic inflammatory response in the postpartum period and a potential basis for developing rapid diagnostic algorithms for early detection of complications.

Keywords:

postpartum inflammatory complications Raman spectroscopy prognostic markers C-reactive protein procalcitonin interleukin-6 neutrophil-lymphocyte ratio fibrinogen oxidative stress early diagnosis

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 51-55
УДК 618.7-002.3:618.714-007.16

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-51-55