CYTOKINE CHANGES FOLLOWING ADJUNCTIVE ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE OR CURCUMIN IN PERIODONTITIS

Authors:

Abstract:

This clinical study assessed changes in periodontal parameters and tissue levels of TNF-α, IL-1β, IL-6, and TGF-β in patients with periodontitis following adjunctive epigallocatechin-3-gallate or curcumin therapy alongside professional mechanical plaque removal over six months. Cytokine levels were measured by ELISA. Adjunctive epigallocatechin-3-gallate or curcumin reduced moderate and deep pockets and bleeding on probing, with curcumin also producing CAL reductions of ≥3/≥4 mm compared to periodontal treatment alone. Gingival IL-10 levels increased while TGF-β1 levels decreased significantly under both nutraceuticals, suggesting a link between polyphenol supplementation and immunomodulation. These findings suggest that targeted modulation of pro- and anti-inflammatory cytokines supports sustained clinical improvements and highlight the potential of nutraceuticals as adjuncts in periodontal therapy, with cytokine shifts paralleling clinical recovery and persisting beyond the treatment period.

Keywords:

curcumin epigallocatechin-3-gallate interleukin-1β interleukin -6 periodontitis therapy transforming growth factor-β tumor necrosis factor-α

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 98-102
УДК 616.314.17-002:615.242-085

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-98-102