CLINICAL MANIFESTATIONS OF DIFFERENT ETIOPATHOGENETIC VARIANTS OF CHRONIC NASOPHARYNGITIS

Authors:

Abstract:

The study was devoted to evaluating the clinical manifestations of different etiopathogenetic variants of chronic nasopharyngitis in children, depending on the predominant trigger factors of exacerbations under different associated conditions of the nasopharyngeal zone. A total of 214 children with confirmed chronic nasopharyngitis were divided into three groups: 62 with isolated chronic nasopharyngitis, 41 with chronic nasopharyngitis associated with pharyngeal tonsil hypertrophy, and 111 with chronic nasopharyngitis associated with allergic rhinitis. The comparison group included 35 children with recurrent respiratory infections and complete recovery between episodes. Retrospective and prospective assessment, clinical examination, videoendoscopic otorhinolaryngological evaluation, allergological testing, cytological analysis, and microbiological study of nasopharyngeal mucus were performed. Children with isolated chronic nasopharyngitis most commonly demonstrated frequent acute viral rhinosinusitis followed by prolonged bacterial activation; those with pharyngeal tonsil hypertrophy showed bacterial predominance in both disease periods; and those with allergic rhinitis exhibited viral-allergic exacerbations with allergic-bacterial persistence between exacerbations.

Keywords:

chronic nasopharyngitis rhinosinusitis recurrent respiratory infections microbiome dysbiosis allergic rhinitis pharyngeal tonsil hypertrophy immunological status

References:

1. Kosakivska IA. Trudnoshchi diahnostyky adenoidnykh vehetatsii u ditei. Sovremennaya pediatriya. 2018;5(93):11-13. DOI: 10.15574/SP.2018.93.11. [in Ukrainian].
2. Kupko N. Suchasni mozhlyvosti likuvannia adenoidytiv u ditei. Dytiachyi likar. 2019;(1):49-55. [in Ukrainian].
3. Ovcharenko LS, Tkachenko VYu, Vertehel AO, Andriienko TH, Samokhin IV, Kriazhev OV, Sheludko DM. Vplyv hiperplazii adenoidiv ta adenotomii na imunitet i stan zdorovia ditei. Zdorove rebenka. 2017;12(4):514-520. DOI: 10.22141/2224-0551.12.4.2017.107634. [in Ukrainian].
4. Pukhlik SM, Zaporozhchenko PO. Suchasni aspekty likuvannia riznykh etiopatohenetychnykh variantiv khronichnoho nazofarynhitu. Otorynolarynholohiia. 2024;(3):18-20. [in Ukrainian].
5. Rohach IM, Keretsman AO, Sitkar AD. Pravylno vybranyy metod statystychnoho analizu – shlyakh do yakisnoyi interpretatsiyi danykh medychnykh doslidzhen. Naukovyy visnyk Uzhhorodskoho universytetu, seriya "Medytsyna". 2017;2(56):124–128. [in Ukrainian].
6. Fesenko MYe, Ziuzina LS, Fastovets MM, Kaliuzhka OO, Melashchenko OI. Hostri respiratorni rekurentni infektsii u ditei. Aktualni problemy suchasnoi medytsyny: Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii. 2019;19(4):34-38. DOI: 10.31718/2077-1096.19.4.34. [in Ukrainian].
7. Khyts AR. Suchasni pohliady na rynity ta novi mozhlyvosti terapii. Ukrayinskyi medychnyi chasopys. 2021 Sep 16. [in Ukrainian].
8. Yurochko FB, Kopanska DB. Suchasna diahnostyka ta likuvannia khvorob adenoidiv. Zdorovia Ukrainy. Tematychnyi nomer "Pediatriia". 2021;4(60). [in Ukrainian].
9. Bulfamante AM, Saibene AM, Felisati G, Rosso C, Pipolo C. Adenoidal Disease and Chronic Rhinosinusitis in Children-Is There a Link? J Clin Med. 2019;8(10):1528. DOI: 10.3390/jcm8101528.
10. Ikramova FS. Treatment of Chronic Adenoiditis in Children. International Journal of Integrative and Modern Medicine. 2023;1(2):61-65.
11. Koshel IV, Leta OI, Bahrii MM. Morphological Justification of Immunorehabilitation Therapy of Chronic Nasopharyngitis Associated with EBV. Art of Medicine. 2022;3(23):58-63. DOI: 10.21802/artm.2022.3.23.58.
12. Ressing ME, van Gent M, Gram AM, Hooykaas MJG, Piersma SJ, Wiertz EJHJ. Immune Evasion by Epstein-Barr Virus. Curr Top Microbiol Immunol. 2015;391:355-381. DOI: 10.1007/978-3-319-22834-1_12.

Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 118-124
УДК 616.321-002:616-092

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-118-124