ALVEOLAR BONE CHANGES IN EARLY STAGES OF CHRONIC KIDNEY DISEASE PATIENTS WITH CHRONIC GENERALIZED PERIODONTITIS

Authors:

Abstract:

With the purpose to investigate the radio-densitometric characteristics of the mandible in patients with chronic kidney disease and chronic generalized periodontitis in total 110 patients were involved. The subjects were submitted to dual-energy X-ray absorptiometry. The vertical density values also showed considerable variation, ranging from 94.3 to 123 arbitrary units. The bone density along the alveolar horizontal line (toward the focus of destruction) was 71.6±5.12 arbitrary units, while along the middle horizontal line, they ranged from 72 to 103.8 arbitrary units. In patients with mix form of destruction showed that in patient with mild chronic generalized periodontitis alveolar horizontal measurement was 83.5±3.54 arbitrary units, in those with moderate chronic generalized periodontitis – 71.6±2.55 arbitrary units. Vertical measurement results ranged from 39.1 to 117.3 arbitrary units. Thus, patients with chronic kidney disease and chronic generalized periodontitis exhibit significant alterations in alveolar bone mineral density, which correlate with the severity of periodontal destruction.

Keywords:

chronic kidney disease chronic generalized periodontitis osteoporosis

References:

1. Chapple ILC, Hirschfeld J, Cockwell P, Dietrich T, Sharma P. Interplay between periodontitis and chronic kidney disease. Nat Rev Nephrol. 2025 Apr;21(4):226-240. doi: 10.1038/s41581-024-00910-5.
2. Hickey N, Shalamanova L, Whitehead K, Dempsey-Hibbert N, van der Gast C, Taylor R. Exploring the putative interactions between chronic kidney disease and chronic periodontitis. Critical Reviews in Microbiology. 2020; 46. 10.1080/1040841X.2020.1724872.
3. Kanjevac T, Bijelic B, Brajkovic D, Vasovic M, Stolic R. Impact of Chronic Kidney Disease Mineral and Bone Disorder on Jaw and Alveolar Bone Metabolism: A Narrative Review. Oral Health Prev Dent. 2018;16(1):79-85. doi: 10.3290/j.ohpd.a39858.
4. Levey AS, Eckardt KU, Dorman NM, Christiansen SL, Hoorn EJ, Ingelfinger JR, et al. Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference. Kidney Int. 2020 Jun;97(6):1117-1129. doi: 10.1016/j.kint.2020.02.010.
5. Martínez Nieto M, De Leon Rodríguez ML, Anaya Macias RDC, Lomelí Martínez SM. Periodontitis and chronic kidney disease: A bidirectional relationship based on inflammation and oxidative stress. World J Clin Cases. 2024 Dec 16;12(35):6775-6781. doi: 10.12998/wjcc.v12.i35.6775.
6. Putra RH, Cooray U, Nurrachman AS, Yoda N, Judge R, Putri DK, et al. Radiographic alveolar bone assessment in correlation with primary implant stability: A systematic review and meta-analysis. Clinical oral implants research. 2024; 35 (1): 1-20. doi:10.1111/clr.14195.
7. Schütz JDS, de Azambuja CB, Cunha GR, Cavagni J, Rösing CK, Haas AN, et al. Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross-sectional study. Oral Dis. 2020 Mar;26(2):447-456. doi: 10.1111/odi.13236.
8. Sharma P, Fenton A, Dias IHK, Heaton B, Brown CLR, Sidhu A, et al. Oxidative stress links periodontal inflammation and renal function. J Clin Periodontol. 2021 Mar;48(3):357-367. doi: 10.1111/jcpe.13414.
9. Sun K, Shen H, Liu Y, Deng H, Chen H, Song Z. Assessment of Alveolar Bone and Periodontal Status in Peritoneal Dialysis Patients. Front Physiol. 2021 Dec 13;12:759056. doi: 10.3389/fphys.2021.759056.
10. Vanholder R, Annemans L, Bello AK, Bikbov B, Gallego D, Gansevoort RT, et al. Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney. Clin Kidney J. 2021 Apr 20;14(7):1719-1730. doi: 10.1093/ckj/sfab070.

Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 165-169
УДК 617.5:616.31:572.7

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-165-169